PMID- 18439988
OWN - NLM
STAT- MEDLINE
DCOM- 20080826
LR  - 20080521
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 1212
DP  - 2008 May 30
TI  - Repeated application of an electric field increases BDNF in the brain, enhances 
      spatial learning, and induces infarct tolerance.
PG  - 79-88
LID - 10.1016/j.brainres.2008.03.011 [doi]
AB  - Development of a safe method to increase brain-derived neurotrophic factor (BDNF) 
      in the brain is expected to have utility in enhancing learning and memory, in 
      protecting the brain, and in suppressing appetite. We investigated the effects of 
      whole-body exposure to high voltage electric potential (HELP), which generates an 
      electric field and current density in the body, on BDNF levels in the brain, 
      spatial learning, or resistance to cerebral infarction development after focal 
      ischemia. Adult mice (C57BL/6J) were exposed to 3.5 kV, or 5.8 kV for 5 h a day, 
      making indirect contact with the ground via room air, over 1, 3, 6 or 12 
      consecutive weeks. After treatment, BDNF levels, performances in the Morris water 
      maze task (MWM), or development of infarct lesion after focal ischemia was 
      analyzed. Treatment with 3.5 kV for 1, 3, 6 or 12 weeks, or with 5.8 kV for 1, 3 
      or 12 weeks increased BDNF levels in the cortex (P<0.05, one-way ANOVA). Every 
      HELP treatment differentially improved escape latency in the MWM, compared with 
      the corresponding untreated controls (P<0.05, one-way ANOVA). Treatment with 3.5 
      kV for 6 or 12 weeks, but not with 5.8 kV protected the brain suppressing 
      cerebral infarction development (P<0.05). The HELP treatment with 3.5 kV for 6 or 
      12 weeks improves spatial learning, gently suppressing body weight gain, and 
      protects the brain against cerebral infarction.
FAU - Yanamoto, Hiroji
AU  - Yanamoto H
AD  - Laboratory for Cerebrovascular Disorders, Research Institute of National 
      Cardio-Vascular Center, Suita, Osaka 565-8565, Japan. hyanamot@res.ncvc.go.jp
FAU - Miyamoto, Susumu
AU  - Miyamoto S
FAU - Nakajo, Yukako
AU  - Nakajo Y
FAU - Nakano, Yoshikazu
AU  - Nakano Y
FAU - Hori, Takuya
AU  - Hori T
FAU - Naritomi, Hiroaki
AU  - Naritomi H
FAU - Kikuchi, Haruhiko
AU  - Kikuchi H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080320
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Blood Pressure/radiation effects
MH  - Brain/*physiology/*radiation effects
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cerebral Infarction/etiology/*prevention & control
MH  - Cerebrovascular Circulation/radiation effects
MH  - Dose-Response Relationship, Radiation
MH  - Electromagnetic Fields/*adverse effects
MH  - Heart Rate/radiation effects
MH  - Ischemia/complications
MH  - Learning/*radiation effects
MH  - Male
MH  - Maze Learning/radiation effects
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Spatial Behavior/*radiation effects
MH  - Swimming
MH  - Time Factors
EDAT- 2008/04/29 09:00
MHDA- 2008/08/30 09:00
CRDT- 2008/04/29 09:00
PHST- 2007/11/28 00:00 [received]
PHST- 2008/02/29 00:00 [revised]
PHST- 2008/03/02 00:00 [accepted]
PHST- 2008/04/29 09:00 [pubmed]
PHST- 2008/08/30 09:00 [medline]
PHST- 2008/04/29 09:00 [entrez]
AID - S0006-8993(08)00573-8 [pii]
AID - 10.1016/j.brainres.2008.03.011 [doi]
PST - ppublish
SO  - Brain Res. 2008 May 30;1212:79-88. doi: 10.1016/j.brainres.2008.03.011. Epub 2008 
      Mar 20.