PMID- 18442010 OWN - NLM STAT- MEDLINE DCOM- 20080528 LR - 20190402 IS - 0304-4920 (Print) IS - 0304-4920 (Linking) VI - 50 IP - 6 DP - 2007 Dec 31 TI - Immunoglobulin E and matrix metalloproteinase-9 in patients with different stages of coronary artery diseases. PG - 277-82 AB - The aims of this study were to identify levels of total immunoglobulin E (IgE) and matrix metalloproteinase (MMP)-9 in patients with different stages of coronary artery diseases. IgE, MMP-9, creatine phosphokinase (CPK), lactate dehydrogenase (LDH), total cholesterol, low density lipoprotein cholesterol (LDL), high density lipoprotein cholesterol (HDL) and triglyceride (TG) were measured by fluorescence enzyme immunoassay, gelatin zymography, and autoanalyzer in normal subjects (n = 40), patients with stable angina pectoris (SAP, n = 40), patients with unstable angina pectoris (UAP, n = 40), patients with acute myocardial infarction (AMI, n = 40), or post-CABG-surgery of those acute myocardial infarction (P-CABG, n = 40). Compared with normal subjects, increased IgE but unchanged MMP-9, CPK, LDH were found in SAP group and UAP group, whereas IgE, MMP-9, CPK and LDH levels were all significantly increased in AMI group. IgE, MMP-9, CPK and LDH levels in P-CABG group were significantly reduced, compared with AMI group, and were similar to those in normal subjects. Cholesterol, LDL, HDL and TG were not significantly changed in all groups. We suggest that serum total IgE can be an early marker of coronary artery disease and MMP-9 is a marker of acute myocardial infarction. FAU - Jong, Gwo-Ping AU - Jong GP AD - Division of Cardiology, Armed Force Taichung General Hospital, Taichung, Taiwan, ROC. FAU - Wang, Yuh-Feng AU - Wang YF FAU - Tsai, Fuu-Jen AU - Tsai FJ FAU - Tsai, Chang-Hai AU - Tsai CH FAU - Wu, Ching-Lin AU - Wu CL FAU - Liu, Rosa Huang AU - Liu RH FAU - Hsieh, Dennis Jine-Yuan AU - Hsieh DJ FAU - Ko, Fu-Yang AU - Ko FY FAU - Huang, Chih-Yang AU - Huang CY FAU - Lee, Shin-Da AU - Lee SD LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - India TA - Chin J Physiol JT - The Chinese journal of physiology JID - 7804502 RN - 0 (Cholesterol, HDL) RN - 0 (Lipids) RN - 0 (Triglycerides) RN - 37341-29-0 (Immunoglobulin E) RN - 9000-70-8 (Gelatin) RN - 97C5T2UQ7J (Cholesterol) RN - EC 1.1.1.27 (L-Lactate Dehydrogenase) RN - EC 2.6.1.1 (Aspartate Aminotransferases) RN - EC 2.7.3.2 (Creatine Kinase) RN - EC 3.4.24.24 (Matrix Metalloproteinase 2) RN - EC 3.4.24.35 (Matrix Metalloproteinase 9) SB - IM MH - Aged MH - Angina Pectoris/metabolism MH - Angina, Unstable/metabolism MH - Aspartate Aminotransferases/blood MH - Cholesterol/blood MH - Cholesterol, HDL/blood MH - Coronary Artery Bypass MH - Coronary Artery Disease/immunology/*metabolism MH - Creatine Kinase/blood MH - Disease Progression MH - Female MH - Gelatin/blood MH - Humans MH - Immunoglobulin E/blood/*metabolism MH - L-Lactate Dehydrogenase/blood MH - Lipids/blood MH - Male MH - Matrix Metalloproteinase 2/blood MH - Matrix Metalloproteinase 9/*metabolism MH - Middle Aged MH - Postoperative Period MH - Triglycerides/blood EDAT- 2008/04/30 09:00 MHDA- 2008/05/29 09:00 CRDT- 2008/04/30 09:00 PHST- 2008/04/30 09:00 [pubmed] PHST- 2008/05/29 09:00 [medline] PHST- 2008/04/30 09:00 [entrez] PST - ppublish SO - Chin J Physiol. 2007 Dec 31;50(6):277-82.