PMID- 18444086
OWN - NLM
STAT- MEDLINE
DCOM- 20080708
LR  - 20211020
IS  - 1538-2443 (Electronic)
IS  - 1355-0284 (Linking)
VI  - 14
IP  - 2
DP  - 2008 Apr
TI  - Lack of immune responses against multiple sclerosis-associated retrovirus/human 
      endogenous retrovirus W in patients with multiple sclerosis.
PG  - 143-51
LID - 10.1080/13550280801958922 [doi]
AB  - The multiple sclerosis-associated retrovirus (MSRV), originally identified in 
      cell cultures from patients with multiple sclerosis (MS), is closely related to 
      the human endogenous retrovirus family type W (HERV-W). Different lines of 
      evidence appear compatible with a potential role of MSRV/HERV-W in the 
      pathogenesis of MS. The authors therefore analyzed humoral and cellular immune 
      responses against MSRV/HERV-W antigens in patients with MS, patients with other 
      inflammatory and noninflammatory neurological diseases, and healthy controls, 
      using indirect immunofluorescence and enzyme-linked immunospot assays. Antibodies 
      against the HERV-W envelope (Env) protein, Syncytin-1, were found in one of 50 
      patients with MS and none of 59 controls, whereas antibodies against MSRV matrix 
      and capsid (Gag) or Env proteins were not detectable in any of the patients or 
      controls. Similarly, in a screening of human leukocyte antigen (HLA)-B7+ patients 
      with MS (n = 23) and controls (n = 29) for cytotoxic T-lymphocyte responses 
      against 36 predicted HLA-B7-restricted MSRV/HERV-W Gag-, protease-, and reverse 
      transcriptase-derived peptides, no such responses could be detected in any of the 
      subjects studied. These data suggest that there are no appreciable humoral or 
      cellular immune responses against MSRV/HERV-W in patients with MS. While this may 
      be due to immunological tolerance of physiologically expressed HERV-W proteins, 
      strategies other than measurement of immune responses will be required to further 
      elucidate the relationship between MSRV/HERV-W and MS.
FAU - Ruprecht, Klemens
AU  - Ruprecht K
AD  - Institute for Virology, Saarland University Hospital, Homburg/Saar, Germany. 
      klemens.ruprecht@uniklinikum-saarland.de
FAU - Gronen, Felix
AU  - Gronen F
FAU - Sauter, Marlies
AU  - Sauter M
FAU - Best, Barbara
AU  - Best B
FAU - Rieckmann, Peter
AU  - Rieckmann P
FAU - Mueller-Lantzsch, Nikolaus
AU  - Mueller-Lantzsch N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurovirol
JT  - Journal of neurovirology
JID - 9508123
RN  - 0 (Antibodies, Viral)
RN  - 0 (Cytokines)
RN  - 0 (Gene Products, env)
RN  - 0 (Pregnancy Proteins)
RN  - 0 (syncytin)
SB  - IM
MH  - Antibodies, Viral/*analysis
MH  - Cohort Studies
MH  - Cytokines/*biosynthesis
MH  - Endogenous Retroviruses/*immunology
MH  - Gene Products, env/metabolism
MH  - Humans
MH  - Multiple Sclerosis/blood/*immunology/*virology
MH  - Pregnancy Proteins/metabolism
EDAT- 2008/04/30 09:00
MHDA- 2008/07/09 09:00
CRDT- 2008/04/30 09:00
PHST- 2008/04/30 09:00 [pubmed]
PHST- 2008/07/09 09:00 [medline]
PHST- 2008/04/30 09:00 [entrez]
AID - 792702467 [pii]
AID - 10.1080/13550280801958922 [doi]
PST - ppublish
SO  - J Neurovirol. 2008 Apr;14(2):143-51. doi: 10.1080/13550280801958922.