PMID- 18445104
OWN - NLM
STAT- MEDLINE
DCOM- 20080701
LR  - 20151119
IS  - 1530-0277 (Electronic)
IS  - 0145-6008 (Linking)
VI  - 32
IP  - 6
DP  - 2008 Jun
TI  - The association between alcohol consumption and biomarkers of alcohol exposure 
      with total serum immunoglobulin E levels.
PG  - 983-90
LID - 10.1111/j.1530-0277.2008.00655.x [doi]
AB  - BACKGROUND: A number of studies have shown that self-reported alcohol intake is 
      positively associated with total serum immunoglobin E (IgE) levels. The purpose 
      of the present study was to investigate the association of self-reported alcohol 
      consumption and different biomarkers of alcohol exposure to total serum IgE 
      levels in a general adult population. METHODS: A total of 3,443 subjects aged 20 
      to 79 years from the population-based cross-sectional Study of Health in 
      Pomerania (SHIP) were included in the analyses. Information on alcohol 
      consumption and serum carbohydrate-deficient transferrin (CDT), gamma-glutamyl 
      transferase (GGT), aspartate-amino transferase (ASAT), andalanine-amino 
      transferase (ALAT) levels were measured. Multivariable linear regression models 
      were performed separately in atopic and nonatopic subjects. RESULTS: In nonatopic 
      subjects positive associations between self-reported alcohol consumption as well 
      as all considered biomarkers of alcohol exposure and total serum IgE levels were 
      found. Further the results also suggested positive associations between alcohol 
      consumption as well as alcohol biomarkers and total serum IgE level in atopic 
      subjects, even though not all tests for linear trend reached statistical 
      significance. CONCLUSIONS: In conclusion, biomarkers of alcohol exposure were 
      positively associated with total serum IgE levels supporting that the positive 
      association between self-reported alcohol intake and IgE levels observed in 
      previous studies is real and not due to misclassification of alcohol intake or 
      confounding by other factors that may be linked to both alcohol intake and total 
      serum IgE levels.
FAU - Friedrich, Nele
AU  - Friedrich N
AD  - Institute for Community Medicine, Ernst Moritz Arndt University, Greifswald, 
      Germany. nele.friedrich@uni-greifswald.de
FAU - Husemoen, Lise Lotte N
AU  - Husemoen LL
FAU - Petersmann, Astrid
AU  - Petersmann A
FAU - Nauck, Matthias
AU  - Nauck M
FAU - Volzke, Henry
AU  - Volzke H
FAU - Linneberg, Allan
AU  - Linneberg A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080426
PL  - England
TA  - Alcohol Clin Exp Res
JT  - Alcoholism, clinical and experimental research
JID - 7707242
RN  - 0 (Biomarkers)
RN  - 0 (Transferrin)
RN  - 0 (carbohydrate-deficient transferrin)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 2.3.2.2 (gamma-Glutamyltransferase)
RN  - EC 2.6.1.1 (Aspartate Aminotransferases)
RN  - EC 2.6.1.2 (Alanine Transaminase)
SB  - IM
MH  - Adult
MH  - Alanine Transaminase/blood
MH  - Alcohol Drinking/*blood/*immunology
MH  - Aspartate Aminotransferases/blood
MH  - Asthma/blood/immunology
MH  - Biomarkers/*blood
MH  - Female
MH  - Humans
MH  - Hypersensitivity/blood/immunology
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Middle Aged
MH  - Rhinitis, Allergic, Seasonal/blood/immunology
MH  - Transferrin/analogs & derivatives/analysis
MH  - gamma-Glutamyltransferase/blood
EDAT- 2008/05/01 09:00
MHDA- 2008/07/02 09:00
CRDT- 2008/05/01 09:00
PHST- 2008/05/01 09:00 [pubmed]
PHST- 2008/07/02 09:00 [medline]
PHST- 2008/05/01 09:00 [entrez]
AID - ACER655 [pii]
AID - 10.1111/j.1530-0277.2008.00655.x [doi]
PST - ppublish
SO  - Alcohol Clin Exp Res. 2008 Jun;32(6):983-90. doi: 
      10.1111/j.1530-0277.2008.00655.x. Epub 2008 Apr 26.