PMID- 18445887
OWN - NLM
STAT- MEDLINE
DCOM- 20080724
LR  - 20161124
IS  - 0917-5857 (Print)
IS  - 0917-5857 (Linking)
VI  - 18
IP  - 5
DP  - 2008 May
TI  - [Relationship between lipid and glucose metabolism and bone mineral metabolism : 
      pleiotropic effects of therapeutic agents for diabetes and hyperlipidemia].
PG  - 671-6
AB  - Bone mineral metabolism and bone remodeling involve a variety of molecules, for 
      instance, bone morphogenetic proteins (BMPs) , fibroblast growth factors (FGFs) , 
      insulin growth factors (IGFs) , interleukin-1 (IL-1) , prostagrandin E(2) 
      (PGE(2)) , and tumor necrosis factor-alpha (TNF-alpha) . Most of them are also 
      involved in lipid and glucose metabolism. Recent in vitro and in vivo studies 
      have reported that therapeutic agents for diabetes and hyperlipidemia, such as 
      insulin, thiazolidinediones, and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) 
      reductase inhibitors (statins) have pleiotropic effects on bone mineral 
      metabolism. These agents may be useful tools for treatment of bone and mineral 
      disorders.
FAU - Hamada, Yasuhiro
AU  - Hamada Y
AD  - Kobe University School of Medicine, Division of Nephrology and Kidney Center.
FAU - Fukagawa, Masafumi
AU  - Fukagawa M
LA  - jpn
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Clin Calcium
JT  - Clinical calcium
JID - 9433326
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
RN  - 0 (Leptin)
RN  - 0 (Thiazolidinediones)
RN  - AA68LXK93C (2,4-thiazolidinedione)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Animals
MH  - Bone Density
MH  - Bone Remodeling
MH  - Bone and Bones/*metabolism
MH  - Calcification, Physiologic/drug effects
MH  - *Carbohydrate Metabolism
MH  - Glucose/*metabolism
MH  - Humans
MH  - Hydroxymethylglutaryl-CoA Reductase Inhibitors/*pharmacology
MH  - Hypoglycemic Agents/*pharmacology
MH  - Insulin/pharmacology
MH  - Leptin/pharmacology
MH  - *Lipid Metabolism
MH  - Osteogenesis/drug effects
MH  - Thiazolidinediones/pharmacology
RF  - 18
EDAT- 2008/05/01 09:00
MHDA- 2008/07/25 09:00
CRDT- 2008/05/01 09:00
PHST- 2008/05/01 09:00 [pubmed]
PHST- 2008/07/25 09:00 [medline]
PHST- 2008/05/01 09:00 [entrez]
AID - 0805671676 [pii]
PST - ppublish
SO  - Clin Calcium. 2008 May;18(5):671-6.