PMID- 18446123
OWN - NLM
STAT- MEDLINE
DCOM- 20080826
LR  - 20161026
IS  - 0021-9509 (Print)
IS  - 0021-9509 (Linking)
VI  - 49
IP  - 3
DP  - 2008 Jun
TI  - Reduced transfusion requirements with a closed cardiopulmonary bypass system.
PG  - 363-9
AB  - AIM: The aim of this investigation is to reduce blood transfusion in cardiac 
      surgery patients with preoperative conditions predictive for transfusion 
      requirements. We compared the amount of blood transfused in two groups of 
      patients undergoing cardiopulmonary bypass (CPB) with two different circuit 
      systems. METHODS: Sixty patients undergoing cardiac surgery were randomly 
      assigned to two groups: in group A (N=30) cardiopulmonary bypass was accomplished 
      with an open circuit and in group B (N=30) with a closed circuit. The open 
      circuit consisted of a cardiotomy reservoir, a membrane oxygenator and an 
      arterial line filter, while the closed circuit was made up of a collapsible 
      venous reservoir, a membrane oxygenator, an arterial line filter and a cardiotomy 
      reservoir. The amount of transfused packed red cells in each patient was measured 
      until discharge from the hospital. RESULTS: Groups were similar regarding age, 
      gender, body surface area (BSA), New York Heart Association (NYHA) class and 
      comorbidity risk factors. Moreover, there were no significant differences between 
      groups regarding the type of procedures, CPB and aortic cross-clamp times, total 
      amount of cardioplegia and urinary output during CPB. Priming volume was 
      1180+/-84 mL (group A) and 760+/-72 mL (group B) (P<0.001). Significant 
      differences in transfusion requirements emerged in the two groups: the total 
      volume of packed red cells transfused for each patient was significantly higher 
      in the open system group compared to the closed system group (717+/-486 mL versus 
      378+/-364 mL) (P=0.003). Clinical outcomes were similar in both groups. 
      CONCLUSION: In patients with preoperative conditions predictive for the need of 
      transfusions, the use of a closed cardiopulmonary bypass circuit can diminish the 
      amount of transfused blood products.
FAU - Casalino, S
AU  - Casalino S
AD  - Department of Anesthesia, San Gaudenzio Clinic, Novara, Italy. 
      casalino63@libero.it
FAU - Stelian, E
AU  - Stelian E
FAU - Novelli, E
AU  - Novelli E
FAU - De Jong, A
AU  - De Jong A
FAU - Renzi, L
AU  - Renzi L
FAU - Arellano, F
AU  - Arellano F
FAU - Mangia, F
AU  - Mangia F
FAU - Ricci, I
AU  - Ricci I
FAU - Lanzillo, G
AU  - Lanzillo G
FAU - Diena, M
AU  - Diena M
FAU - Tesler, U F
AU  - Tesler UF
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Italy
TA  - J Cardiovasc Surg (Torino)
JT  - The Journal of cardiovascular surgery
JID - 0066127
SB  - IM
MH  - Aged
MH  - Blood Transfusion/*statistics & numerical data
MH  - Cardiopulmonary Bypass/*instrumentation
MH  - Chi-Square Distribution
MH  - Female
MH  - Humans
MH  - Male
MH  - Predictive Value of Tests
MH  - Risk Assessment
EDAT- 2008/05/01 09:00
MHDA- 2008/08/30 09:00
CRDT- 2008/05/01 09:00
PHST- 2008/05/01 09:00 [pubmed]
PHST- 2008/08/30 09:00 [medline]
PHST- 2008/05/01 09:00 [entrez]
PST - ppublish
SO  - J Cardiovasc Surg (Torino). 2008 Jun;49(3):363-9.