PMID- 18446610
OWN - NLM
STAT- MEDLINE
DCOM- 20080718
LR  - 20191110
IS  - 1061-186X (Print)
IS  - 1026-7158 (Linking)
VI  - 16
IP  - 4
DP  - 2008 May
TI  - Chloramphenicol-incorporated poly lactide-co-glycolide (PLGA) nanoparticles: 
      formulation, characterization, technetium-99m labeling and biodistribution 
      studies.
PG  - 311-20
LID - 10.1080/10611860801899300 [doi]
AB  - Chloramphenicol-loaded (CHL) poly-d,l-lactic-co-glycolic acid (PLGA) 
      nanoparticles (NPs) were prepared by emulsification solvent evaporation technique 
      either by using polyvinyl alcohol (PVA) as emulsion stabilizer or polysorbate-80 
      (PS-80) as surfactant and characterised by transmission electron microscopy, 
      zeta-potential measurements. The NPs were radiolabeled with technetium-99m 
      ((99m)Tc) by stannous reduction method. Labeling conditions were optimised to 
      achieve high-labeling efficiency, in vitro and in vivo (serum) stability. The 
      labeled complexes also showed very low transchelation as determined by DTPA 
      challenge test. Biodistribution studies of (99m)Tc-labeled complexes were 
      performed after intravenous administration in mice. The CHL-loaded PLGA NPs 
      coated with PS-80 exhibited relatively high brain uptake with comparatively low 
      accumulation in bone marrow to that of free drug and CHL-loaded PLGA NPs (PVA, 
      used as emulsion stabilizer) at 24 h post injection time period. This indicates 
      the usefulness of the above delivery system for prolonged use of the antibiotic.
FAU - Halder, Kamal Krishna
AU  - Halder KK
AD  - Nuclear Medicine Division, Indian Institute of Chemical Biology, Kolkata, India.
FAU - Mandal, Bivash
AU  - Mandal B
FAU - Debnath, Mita Chatterjee
AU  - Debnath MC
FAU - Bera, Hriday
AU  - Bera H
FAU - Ghosh, Lakshmi Kanto
AU  - Ghosh LK
FAU - Gupta, Bijon Kumar
AU  - Gupta BK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Drug Target
JT  - Journal of drug targeting
JID - 9312476
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Chelating Agents)
RN  - 0 (Tin Compounds)
RN  - 1BQV3749L5 (stannous chloride)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 66974FR9Q1 (Chloramphenicol)
RN  - 7440-26-8 (Technetium)
RN  - 7A314HQM0I (Pentetic Acid)
SB  - IM
MH  - Animals
MH  - Anti-Bacterial Agents/administration & dosage/pharmacokinetics/*pharmacology
MH  - Chelating Agents/chemistry
MH  - Chemical Phenomena
MH  - Chemistry, Pharmaceutical
MH  - Chemistry, Physical
MH  - Chloramphenicol/administration & dosage/pharmacokinetics/*pharmacology
MH  - Drug Stability
MH  - Electrochemistry
MH  - Hydrogen-Ion Concentration
MH  - Injections, Intravenous
MH  - Isotope Labeling
MH  - Lactic Acid
MH  - Mice
MH  - Microscopy, Electron, Transmission
MH  - Nanoparticles
MH  - Pentetic Acid/chemistry
MH  - Polyglycolic Acid
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Technetium
MH  - Tin Compounds/chemistry
MH  - Tissue Distribution
EDAT- 2008/05/01 09:00
MHDA- 2008/07/19 09:00
CRDT- 2008/05/01 09:00
PHST- 2008/05/01 09:00 [pubmed]
PHST- 2008/07/19 09:00 [medline]
PHST- 2008/05/01 09:00 [entrez]
AID - 792747229 [pii]
AID - 10.1080/10611860801899300 [doi]
PST - ppublish
SO  - J Drug Target. 2008 May;16(4):311-20. doi: 10.1080/10611860801899300.