PMID- 18446719
OWN - NLM
STAT- MEDLINE
DCOM- 20080826
LR  - 20181201
IS  - 1121-8428 (Print)
IS  - 1121-8428 (Linking)
VI  - 21
IP  - 2
DP  - 2008 Mar-Apr
TI  - Intravenous iron without erythropoietin for the treatment of iron deficiency 
      anemia in patients with moderate to severe congestive heart failure and chronic 
      kidney insufficiency.
PG  - 236-42
AB  - OBJECTIVES: Iron deficiency anemia is a frequent finding in many patients with 
      congestive heart failure (CHF). The purpose of this study was to assess the 
      effect of intravenous (i.v.) iron on the anemia of CHF patients and on cardiac 
      remodeling, New York Heart Association (NYHA) classification and renal function. 
      METHODS: Thirty-two patients with well-treated CHF which was NYHA class III-IV, 
      and with hemoglobin (Hb) persistently <11 g/dL, were treated with i.v. iron over 
      26 weeks. Echocardiographic, hematological and renal parameters were measured at 
      the beginning and end of the study. RESULTS: Hb increased significantly from 10.7 
      +/- 0.4 g/dL to 13.7 +/- 0.4 g/dL and from 9.4 +/- 0.6 g/dL to 12.7+/- 0.8 g/dL 
      in the NYHA III and IV groups respectively. Posterior wall thickness, septal 
      thickness (ST), left ventricular (LV) end diastolic volume and diameter, LV end 
      systolic volume and diameter, LV mass index and LV ejection fraction (LVEF) were 
      all abnormal initially. All of these parameters improved significantly in the 
      NYHA III patients, and all but ST and LVEF improved significantly in the NYHA IV 
      patients. NYHA classification improved from III to II in 9 of 19 NYHA III 
      patients (47.4%) (p<0.01) but did not improve in any of the 13 NYHA IV patients. 
      CONCLUSION: Intravenous iron causes a marked increase in hemoglobin in anemic CHF 
      patients, and this is frequently associated with an improvement in cardiac 
      remodeling and NYHA classification.
FAU - Usmanov, Rustam I
AU  - Usmanov RI
AD  - Republican Research Center of Emergency Medicine of Uzbekistan, Tashkent, 
      Uzbekistan.
FAU - Zueva, Elena B
AU  - Zueva EB
FAU - Silverberg, Donald S
AU  - Silverberg DS
FAU - Shaked, Meital
AU  - Shaked M
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - J Nephrol
JT  - Journal of nephrology
JID - 9012268
RN  - 0 (Ferric Compounds)
RN  - 0 (Hemoglobins)
RN  - 0 (Transferrin)
RN  - 9007-73-2 (Ferritins)
RN  - AYI8EX34EU (Creatinine)
RN  - E1UOL152H7 (Iron)
RN  - FZ7NYF5N8L (Ferric Oxide, Saccharated)
RN  - QLZ991V4A2 (Glucaric Acid)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Anemia, Iron-Deficiency/blood/complications/*drug therapy
MH  - Creatinine/blood
MH  - Echocardiography
MH  - Female
MH  - Ferric Compounds/*administration & dosage
MH  - Ferric Oxide, Saccharated
MH  - Ferritins/blood
MH  - Glucaric Acid
MH  - Heart Failure/*complications/drug therapy/*physiopathology
MH  - Hemoglobins/analysis
MH  - Humans
MH  - Infusions, Intravenous
MH  - Iron/blood
MH  - Male
MH  - Middle Aged
MH  - Renal Insufficiency, Chronic/blood/*complications
MH  - Transferrin/analysis
EDAT- 2008/05/01 09:00
MHDA- 2008/08/30 09:00
CRDT- 2008/05/01 09:00
PHST- 2008/05/01 09:00 [pubmed]
PHST- 2008/08/30 09:00 [medline]
PHST- 2008/05/01 09:00 [entrez]
PST - ppublish
SO  - J Nephrol. 2008 Mar-Apr;21(2):236-42.