PMID- 18450018
OWN - NLM
STAT- MEDLINE
DCOM- 20080605
LR  - 20191210
IS  - 1064-3745 (Print)
IS  - 1064-3745 (Linking)
VI  - 409
DP  - 2007
TI  - HistoCheck. Evaluating structural and functional MHC similarities.
PG  - 395-405
AB  - The HistoCheck webtool provides clinicians and researchers with a way of 
      visualizing and understanding the structural differences among related major 
      histocompatibility complex (MHC) molecules. In the clinical setting, human 
      leukocyte antigen (HLA) matching of hematopoietic stem cell donors and recipients 
      is essential to minimize "graft versus host disease" (GvHD). Because exact HLA 
      matching is often not possible, it is important to understand which alleles 
      present the same structures (HLA-peptide complexes) to the T-cell receptor (TCR) 
      despite having different amino acid sequences. HistoCheck provides a summary of 
      amino acid mismatches, positions, and functions as well as 3-dimensional (3D) 
      visualizations. In this chapter, we describe how HistoCheck is used and offer 
      advice in interpreting the query results.
FAU - DeLuca, David S
AU  - DeLuca DS
AD  - Institute for Transfusion Medicine, Hannover Medical School Hannover, Germany.
FAU - Blasczyk, Rainer
AU  - Blasczyk R
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Methods Mol Biol
JT  - Methods in molecular biology (Clifton, N.J.)
JID - 9214969
RN  - 0 (HLA Antigens)
RN  - 0 (Multiprotein Complexes)
RN  - 0 (Peptides)
RN  - 0 (Receptors, Antigen, T-Cell)
SB  - IM
MH  - Algorithms
MH  - Alleles
MH  - Computational Biology
MH  - Computer Simulation
MH  - HLA Antigens/*chemistry/genetics/*metabolism
MH  - Humans
MH  - Immunogenetics
MH  - Internet
MH  - *Major Histocompatibility Complex
MH  - Models, Molecular
MH  - Multiprotein Complexes
MH  - Peptides/chemistry/immunology/metabolism
MH  - Protein Binding
MH  - Receptors, Antigen, T-Cell/chemistry/metabolism
MH  - Software
EDAT- 2008/05/03 09:00
MHDA- 2008/06/06 09:00
CRDT- 2008/05/03 09:00
PHST- 2008/05/03 09:00 [pubmed]
PHST- 2008/06/06 09:00 [medline]
PHST- 2008/05/03 09:00 [entrez]
AID - 10.1007/978-1-60327-118-9_30 [doi]
PST - ppublish
SO  - Methods Mol Biol. 2007;409:395-405. doi: 10.1007/978-1-60327-118-9_30.