PMID- 18450249
OWN - NLM
STAT- MEDLINE
DCOM- 20080620
LR  - 20131121
IS  - 0332-3102 (Print)
IS  - 0332-3102 (Linking)
VI  - 101
IP  - 2
DP  - 2008 Feb
TI  - Efficacy of intravenous immunoglobulin in the management of haemolytic disease of 
      the newborn.
PG  - 46-8
AB  - Intravenous immunoglobulin (IVIG) is indicated for use in Rhesus and ABO 
      hemolytic disease of the newborn (HDN) to reduce the need for exchange 
      transfusion, to decrease hospital stay and the duration of phototherapy. 11 
      infants received IVIG and the effect of IVIG on the total serum bilirubin (TSB) 
      level, and its effect on the rate of rise of TSB was quantified. There was a 
      statistically significant decrease in bilirubin levels before and after treatment 
      with IVIG from 234 to 219 micromol/L (p = 0.001). In addition, the rate of change 
      in bilirubin level significantly altered from an upward to a downward trend. (p = 
      0.001). The Number Needed to Treat (NNT) to prevent an exchange transfusion was 
      2.75--comparable with the recent systematic review of IVIG with a NNT of 2.7.
FAU - Walsh, S A
AU  - Walsh SA
AD  - Department of Neonatology, National Maternity Hospital, Holles St, Dublin 2.
FAU - Yao, N
AU  - Yao N
FAU - El-Khuffash, A
AU  - El-Khuffash A
FAU - Twomey, A
AU  - Twomey A
FAU - Molloy, E J
AU  - Molloy EJ
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Ir Med J
JT  - Irish medical journal
JID - 0430275
RN  - 0 (Immunoglobulins, Intravenous)
RN  - RFM9X3LJ49 (Bilirubin)
SB  - IM
MH  - Bilirubin/*blood
MH  - Erythroblastosis, Fetal/blood/*drug therapy/therapy
MH  - Exchange Transfusion, Whole Blood
MH  - Female
MH  - Gestational Age
MH  - Humans
MH  - Immunoglobulins, Intravenous/administration & dosage/*therapeutic use
MH  - Infant, Newborn
MH  - Injections, Intravenous
MH  - Male
MH  - Retrospective Studies
MH  - Treatment Outcome
EDAT- 2008/05/03 09:00
MHDA- 2008/06/21 09:00
CRDT- 2008/05/03 09:00
PHST- 2008/05/03 09:00 [pubmed]
PHST- 2008/06/21 09:00 [medline]
PHST- 2008/05/03 09:00 [entrez]
PST - ppublish
SO  - Ir Med J. 2008 Feb;101(2):46-8.