PMID- 18450649 OWN - NLM STAT- MEDLINE DCOM- 20080911 LR - 20221207 IS - 0022-2275 (Print) IS - 1539-7262 (Electronic) IS - 0022-2275 (Linking) VI - 49 IP - 8 DP - 2008 Aug TI - ESR1 polymorphism is associated with plasma lipid and apolipoprotein levels in Caucasians of the Rochester Family Heart Study. PG - 1701-6 LID - 10.1194/jlr.M700490-JLR200 [doi] AB - We evaluated six estrogen receptor 1 (ESR1) polymorphisms for association with ten plasma lipid and apolipoprotein traits in 1,847 individuals (941 females and 906 males) in the multi-generation Rochester Family Heart Study using a generalized estimating equation approach. Apolipoprotein A-I (apoA-I), apoA-II, and HDL-cholesterol (HDL-C) were associated with exon 4 rs1801132 (Pro325Pro) genotype (P = 0.0044, P = 0.0048, and P = 0.0035, respectively). Positive correlation between levels of apoA-I, apoA-II, and HDL-C and the number of G alleles was observed in females (P = 0.0120, P = 0.0032, and P = 0.0030), but not males (P > 0.05). Because few studies have evaluated the effect of ESR1 gene polymorphisms on lipid traits in children, we also stratified our sample at the age of 15 years. There was evidence of association between intron 1 single-nucleotide polymorphisms rs9322331 and rs9340799 and apoC-II, and triglycerides (TGs) in youths 15 years and younger. In youths, evidence of association between rs9322331 and rs9340799 and apoC-II was stronger in males (P = 0.0036 and P = 0.0124) than in females (P > 0.05), whereas evidence of association with TG was stronger in females (P = 0.0030 and P = 0.0024) than in males (P > 0.05). These findings suggest that ESR1 variation plays an age- and sex-dependent role in determining plasma lipid and apolipoprotein levels. FAU - Klos, Kathy L E AU - Klos KL AD - Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA. kathy.klos@uth.tmc.edu FAU - Boerwinkle, Eric AU - Boerwinkle E FAU - Ferrell, Robert E AU - Ferrell RE FAU - Turner, Stephen T AU - Turner ST FAU - Morrison, Alanna C AU - Morrison AC LA - eng GR - R01 HL077491/HL/NHLBI NIH HHS/United States GR - R37 HL051021-12/HL/NHLBI NIH HHS/United States GR - R37 HL051021-13/HL/NHLBI NIH HHS/United States GR - R37 HL051021-11/HL/NHLBI NIH HHS/United States GR - R37 HL051021-14/HL/NHLBI NIH HHS/United States GR - R37 HL051021-15/HL/NHLBI NIH HHS/United States GR - R01 HL 077491/HL/NHLBI NIH HHS/United States GR - R37 HL051021/HL/NHLBI NIH HHS/United States GR - R37 HL051021-10/HL/NHLBI NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20080430 PL - United States TA - J Lipid Res JT - Journal of lipid research JID - 0376606 RN - 0 (Apolipoprotein A-I) RN - 0 (Apolipoprotein A-II) RN - 0 (Apolipoproteins) RN - 0 (Cholesterol, HDL) RN - 0 (ESR1 protein, human) RN - 0 (Estrogen Receptor alpha) RN - 0 (Triglycerides) SB - IM MH - Adolescent MH - Adult MH - Aged MH - Apolipoprotein A-I/blood MH - Apolipoprotein A-II/blood MH - Apolipoproteins/*blood MH - Cholesterol, HDL/blood MH - Estrogen Receptor alpha/*genetics MH - Female MH - Humans MH - Male MH - Polymorphism, Genetic MH - Triglycerides/*blood MH - White People/*genetics PMC - PMC2637157 EDAT- 2008/05/03 09:00 MHDA- 2008/09/13 09:00 PMCR- 2009/08/01 CRDT- 2008/05/03 09:00 PHST- 2008/05/03 09:00 [pubmed] PHST- 2008/09/13 09:00 [medline] PHST- 2008/05/03 09:00 [entrez] PHST- 2009/08/01 00:00 [pmc-release] AID - S0022-2275(20)34688-5 [pii] AID - jlr4981701 [pii] AID - 10.1194/jlr.M700490-JLR200 [doi] PST - ppublish SO - J Lipid Res. 2008 Aug;49(8):1701-6. doi: 10.1194/jlr.M700490-JLR200. Epub 2008 Apr 30.