PMID- 18451774
OWN - NLM
STAT- MEDLINE
DCOM- 20080912
LR  - 20151119
IS  - 1930-7381 (Print)
IS  - 1930-7381 (Linking)
VI  - 16
IP  - 7
DP  - 2008 Jul
TI  - Inflammatory response to a high-fat, low-carbohydrate weight loss diet: effect of 
      antioxidants.
PG  - 1573-8
LID - 10.1038/oby.2008.252 [doi]
AB  - The objective of this study was to test the hypothesis that the inflammatory 
      response to a high-fat, low-carbohydrate weight loss diet (HF) we previously 
      observed was due to oxidative stress. Nineteen overweight subjects (BMI>27 
      kg/m(2)) were randomly assigned to either an antioxidant supplement (AS) (1 g 
      vitamin C/800 IU vitamin E) or a placebo (P) group and provided with a HF for 7 
      days. Fasted pre- and post serum samples were measured for markers of 
      inflammation (C-reactive protein (CRP), interleukin-6 (IL-6), and monocyte 
      chemoattractant protein-1 (MCP-1)), oxygen radical absorbance capacity (ORAC), 
      and glucose, whereas urine was measured for oxidative stress 
      (8-epi-prostaglandin-F(2alpha) (8-epi)). HF resulted in significant reductions in 
      weight (-3.2%), glucose (-18.7%), and MCP-1 (-15%) (all P<0.01), with no 
      difference between groups. There was a trend for a differential effect between 
      groups for CRP as it decreased 32% in the AS group but increased 50% for P 
      (P=0.076). Inverse correlations were noted between initial values and changes in 
      several inflammatory and oxidative stress markers, including CRP (r= -0.501), 
      8-epi (r= -0.863), and ORAC (r= -0.546) (all P<0.05). It was concluded that 
      weight loss on a short-term HF caused reduction of some but not all markers of 
      inflammation. A role for oxidative stress in causing inflammation was not 
      confirmed; however, longer term diet-controlled studies are necessary to further 
      explore the trend for a differential response in CRP with antioxidant 
      supplementation.
FAU - Peairs, Abigail T
AU  - Peairs AT
AD  - Department of Human Nutrition, Foods, and Exercise, Virginia Tech, Blacksburg, 
      Virginia, USA. aturpyn@vt.edu
FAU - Rankin, Janet W
AU  - Rankin JW
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20080501
PL  - United States
TA  - Obesity (Silver Spring)
JT  - Obesity (Silver Spring, Md.)
JID - 101264860
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Dietary Fats)
RN  - 0 (Drug Combinations)
RN  - 0 (IL6 protein, human)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Interleukin-6)
RN  - 0 (Reactive Oxygen Species)
RN  - 1406-18-4 (Vitamin E)
RN  - 27415-26-5 (8-epi-prostaglandin F2alpha)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - B7IN85G1HY (Dinoprost)
RN  - PQ6CK8PD0R (Ascorbic Acid)
SB  - IM
MH  - Antioxidants/*therapeutic use
MH  - Ascorbic Acid/*therapeutic use
MH  - Biomarkers/metabolism
MH  - Blood Glucose/drug effects
MH  - C-Reactive Protein/metabolism
MH  - Chemokine CCL2/blood
MH  - Diet, Carbohydrate-Restricted/*adverse effects
MH  - Dietary Fats/administration & dosage/*adverse effects
MH  - Dinoprost/analogs & derivatives/urine
MH  - Drug Combinations
MH  - Female
MH  - Humans
MH  - Inflammation/etiology/metabolism/*prevention & control
MH  - Inflammation Mediators/blood
MH  - Interleukin-6/blood
MH  - Male
MH  - Obesity/*diet therapy/*drug therapy/metabolism
MH  - Oxidative Stress/*drug effects
MH  - Reactive Oxygen Species/blood
MH  - Time Factors
MH  - Treatment Outcome
MH  - Vitamin E/therapeutic use
MH  - *Weight Loss
EDAT- 2008/05/03 09:00
MHDA- 2008/09/16 09:00
CRDT- 2008/05/03 09:00
PHST- 2008/05/03 09:00 [pubmed]
PHST- 2008/09/16 09:00 [medline]
PHST- 2008/05/03 09:00 [entrez]
AID - oby2008252 [pii]
AID - 10.1038/oby.2008.252 [doi]
PST - ppublish
SO  - Obesity (Silver Spring). 2008 Jul;16(7):1573-8. doi: 10.1038/oby.2008.252. Epub 
      2008 May 1.