PMID- 18451808
OWN - NLM
STAT- MEDLINE
DCOM- 20081030
LR  - 20161124
IS  - 0895-7061 (Print)
IS  - 0895-7061 (Linking)
VI  - 21
IP  - 7
DP  - 2008 Jul
TI  - Association between hemodynamics in the common carotid artery and severity of 
      carotid atherosclerosis in patients with essential hypertension.
PG  - 765-70
LID - 10.1038/ajh.2008.182 [doi]
AB  - BACKGROUND: Carotid intima-media thickness (IMT) and plaque burden evaluated by 
      B-mode ultrasound have been used as relevant indicators for carotid 
      atherosclerosis. This study was aimed to investigate the relationship between 
      hemodynamic parameters in the common carotid artery (CCA) and the severity of 
      carotid atherosclerosis in untreated hypertensive patients. METHODS: Carotid IMT 
      and plaque burden were evaluated in bilateral CCA, bifurcations, external and 
      internal carotid arteries using duplex ultrasound in 80 untreated hypertensive 
      patients. The patients were divided into four groups according to plaque burden. 
      Hemodynamic parameters of CCA, including peak and mean circumferential wall 
      tension (CWT), tensile stress (TS), wall shear stress (WSS), and Young's elastic 
      modulus (YEM), were calculated after measurements of internal diameter (ID), IMT, 
      and peak and mean flow velocities of CCA. Arterial stiffness was also assessed 
      using the brachial-ankle pulse wave velocity (baPWV). RESULTS: Age, pulse 
      pressure, creatinine, carotid IMT, and mean TS were shown to have significant 
      differences among the four plaque groups (P < 0.05). Peak CWT and peak TS were 
      also shown to have marginal differences. In univariate analysis, the peak and 
      mean CWT and TS were significantly correlated with plaque score. Stepwise 
      multiple regression analysis showed that carotid IMT, age, and peak CWT were 
      independently associated with plaque score. CONCLUSIONS: These results suggest 
      that the CWT and TS of the CCA are associated with the severity of carotid 
      atherosclerosis in untreated hypertensive patients. Hence, the hemodynamics of 
      vessels may contribute to the plaque burden of low-resistance arteries.
FAU - Lee, Min Y
AU  - Lee MY
AD  - Division of Cardiology, Department of Internal Medicine, Kaohsiung Municipal 
      United Hospital, Kaohsiung, Taiwan.
FAU - Wu, Chan M
AU  - Wu CM
FAU - Yu, Kuo H
AU  - Yu KH
FAU - Chu, Chih S
AU  - Chu CS
FAU - Lee, Kun T
AU  - Lee KT
FAU - Sheu, Sheng H
AU  - Sheu SH
FAU - Lai, Wen T
AU  - Lai WT
LA  - eng
PT  - Journal Article
DEP - 20080501
PL  - United States
TA  - Am J Hypertens
JT  - American journal of hypertension
JID - 8803676
SB  - IM
CIN - Am J Hypertens. 2008 Jul;21(7):729. PMID: 18584017
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Ankle/blood supply
MH  - Blood Flow Velocity
MH  - Blood Pressure
MH  - Brachial Artery/physiopathology
MH  - Carotid Artery Diseases/diagnostic imaging/etiology/*physiopathology
MH  - Carotid Artery, Common/diagnostic imaging/*physiopathology
MH  - Cross-Sectional Studies
MH  - Elasticity
MH  - Female
MH  - *Hemodynamics
MH  - Humans
MH  - Hypertension/*complications/diagnostic imaging/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Models, Cardiovascular
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Stress, Mechanical
MH  - Ultrasonography, Doppler, Duplex
EDAT- 2008/05/03 09:00
MHDA- 2008/10/31 09:00
CRDT- 2008/05/03 09:00
PHST- 2008/05/03 09:00 [pubmed]
PHST- 2008/10/31 09:00 [medline]
PHST- 2008/05/03 09:00 [entrez]
AID - ajh2008182 [pii]
AID - 10.1038/ajh.2008.182 [doi]
PST - ppublish
SO  - Am J Hypertens. 2008 Jul;21(7):765-70. doi: 10.1038/ajh.2008.182. Epub 2008 May 
      1.