PMID- 18452823
OWN - NLM
STAT- MEDLINE
DCOM- 20080905
LR  - 20080502
IS  - 1078-1439 (Print)
IS  - 1078-1439 (Linking)
VI  - 26
IP  - 3
DP  - 2008 May-Jun
TI  - Familial papillary renal carcinoma: cytogenetic characterization in normal and 
      tumor tissues in two brothers. A case report.
PG  - 295-8
LID - 10.1016/j.urolonc.2007.01.025 [doi]
AB  - BACKGROUND: Renal tumor subtypes are associated with distinct, recurring 
      cytogenetic abnormalities and hereditary cancer syndromes. In papillary renal 
      carcinoma, trisomy 7 and 17 and loss of the Y chromosome are the most common 
      chromosomal defects. CASE PRESENTATION: The present paper analyzes the 
      chromosomes 7, 17, and Y alterations found in familial papillary carcinoma and in 
      the normal tissue of two brothers. The evaluation, performed by fluorescence in 
      situ hybridization (FISH) and cytogenetic conventional methods, was carried out 
      on blood samples, normal kidney tissue, and tumor samples of the two brothers. 
      Patient 1 showed gains of chromosomes 7 and 17 both in normal and tumor tissue. 
      Chromosome Y status was normal. Patient 2 showed chromosome 7 and 17 gains, 
      chromosome Y loss in tumor and chromosome 17 and Y alterations in normal kidney 
      tissue. The constitutional karyotype was normal in both brothers. CONCLUSIONS: Of 
      particular relevance were the chromosome aberrations found in normal kidney 
      parenchyma. In fact, the progressive alterations of 7, 17, and Y chromosomes 
      could provide evidence of early genetic instability of tissue and may even 
      precede the development of macroscopically identifiable lesions.
FAU - Gallucci, Michele
AU  - Gallucci M
AD  - Department of Urology, Regina Elena Cancer Institute, Rome, Italy.
FAU - Vico, Erika
AU  - Vico E
FAU - Sentinelli, Steno
AU  - Sentinelli S
FAU - Leonardo, Costantino
AU  - Leonardo C
FAU - Visca, Paulo
AU  - Visca P
FAU - Orlandi, Giulia
AU  - Orlandi G
FAU - Cianciulli, AnnaMaria
AU  - Cianciulli A
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20080220
PL  - United States
TA  - Urol Oncol
JT  - Urologic oncology
JID - 9805460
SB  - IM
MH  - Adult
MH  - Carcinoma, Papillary/*genetics/*pathology
MH  - Chromosomes, Human/genetics
MH  - Cytogenetics
MH  - Genetic Predisposition to Disease/*genetics
MH  - *Health
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Kidney Neoplasms/*genetics/*pathology
MH  - Male
MH  - *Siblings
EDAT- 2008/05/03 09:00
MHDA- 2008/09/06 09:00
CRDT- 2008/05/03 09:00
PHST- 2007/01/31 00:00 [received]
PHST- 2007/01/31 00:00 [accepted]
PHST- 2008/05/03 09:00 [pubmed]
PHST- 2008/09/06 09:00 [medline]
PHST- 2008/05/03 09:00 [entrez]
AID - S1078-1439(07)00028-2 [pii]
AID - 10.1016/j.urolonc.2007.01.025 [doi]
PST - ppublish
SO  - Urol Oncol. 2008 May-Jun;26(3):295-8. doi: 10.1016/j.urolonc.2007.01.025. Epub 
      2008 Feb 20.