PMID- 18455294
OWN - NLM
STAT- MEDLINE
DCOM- 20081014
LR  - 20231213
IS  - 0304-3835 (Print)
IS  - 1872-7980 (Electronic)
IS  - 0304-3835 (Linking)
VI  - 268
IP  - 1
DP  - 2008 Sep 8
TI  - Polymorphisms of the DNMT3B gene and risk of squamous cell carcinoma of the head 
      and neck: a case-control study.
PG  - 158-65
LID - 10.1016/j.canlet.2008.03.034 [doi]
AB  - DNA-methyltransferase-3B (DNMT3B) may play an oncogenic role during 
      tumorigenesis, and its genetic variants have been reportedly to be associated 
      with risk of several cancers, but few studies have investigated their roles in 
      squamous cell carcinoma of the head and neck cancer (SCCHN). Here we report a 
      hospital-based case-control study with 832 SCCHN patients and 843 cancer-free 
      controls of non-Hispanic whites that evaluated the association between two DNMT3B 
      single nucleotide polymorphisms (SNPs) DNMT3B -149C>T (rs2424913) and DNMT3B 
      -579G>T (rs2424909) in the promoter region and risk of SCCHN. We found that 
      compared with C-allele carriers, the DNMT3B -149 TT genotype was statistically 
      significantly associated with increased risk of SCCHN (adjusted OR, 1.35, 95% CI, 
      1.01-1.80, P=0.043), whereas the DNMT3B -579 TT genotype showed only a 
      non-statistically significant risk compared with G-allele carriers. Further 
      analysis of the effects of combined genotypes suggested that subjects with either 
      DNMT3B -149 TT or DNMT3B -579 TT homozygous genotypes had statistically 
      significantly increased risk of SCCHN (adjusted OR=1.36, 95% CI=1.07-1.73, 
      P=0.013). Stratification analysis showed a more profound risk in the subgroups of 
      the young (< or =57 years, the median age of the controls), males, current 
      smokers, current drinkers, and patients with primary tumor sites of pharynx and 
      larynx. This large study provides reliable risk estimates for associations 
      between DNMT3B variants and SCCHN risk in non-Hispanic whites, and our findings 
      are consistent with that of previously reported cancer case-control studies of 
      other cancers. Further mechanistic studies are needed to unravel the underlying 
      molecular mechanisms.
FAU - Liu, Zhensheng
AU  - Liu Z
AD  - Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center, 
      Box 189, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
FAU - Wang, Luo
AU  - Wang L
FAU - Wang, Li-E
AU  - Wang LE
FAU - Sturgis, Erich M
AU  - Sturgis EM
FAU - Wei, Qingyi
AU  - Wei Q
LA  - eng
GR  - P30 CA016672/CA/NCI NIH HHS/United States
GR  - CA100264/CA/NCI NIH HHS/United States
GR  - R01 ES011740/ES/NIEHS NIH HHS/United States
GR  - R01 ES011740-06A2/ES/NIEHS NIH HHS/United States
GR  - ES 11740/ES/NIEHS NIH HHS/United States
GR  - CA 16672/CA/NCI NIH HHS/United States
GR  - R01 CA100264/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20080501
PL  - Ireland
TA  - Cancer Lett
JT  - Cancer letters
JID - 7600053
RN  - EC 2.1.1.37 (DNA (Cytosine-5-)-Methyltransferases)
SB  - IM
MH  - Carcinoma, Squamous Cell/*genetics
MH  - Case-Control Studies
MH  - DNA (Cytosine-5-)-Methyltransferases/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Head and Neck Neoplasms/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic
MH  - Risk
MH  - DNA Methyltransferase 3B
PMC - PMC2646006
MID - NIHMS69653
EDAT- 2008/05/06 09:00
MHDA- 2008/10/15 09:00
PMCR- 2009/09/08
CRDT- 2008/05/06 09:00
PHST- 2008/01/30 00:00 [received]
PHST- 2008/03/25 00:00 [revised]
PHST- 2008/03/26 00:00 [accepted]
PHST- 2008/05/06 09:00 [pubmed]
PHST- 2008/10/15 09:00 [medline]
PHST- 2008/05/06 09:00 [entrez]
PHST- 2009/09/08 00:00 [pmc-release]
AID - S0304-3835(08)00247-4 [pii]
AID - 10.1016/j.canlet.2008.03.034 [doi]
PST - ppublish
SO  - Cancer Lett. 2008 Sep 8;268(1):158-65. doi: 10.1016/j.canlet.2008.03.034. Epub 
      2008 May 1.