PMID- 18455630
OWN - NLM
STAT- MEDLINE
DCOM- 20080602
LR  - 20220321
IS  - 1527-9995 (Electronic)
IS  - 0090-4295 (Linking)
VI  - 71
IP  - 5
DP  - 2008 May
TI  - Hyperhomocysteinemia is a risk factor for erectile dysfunction in men with 
      adult-onset diabetes mellitus.
PG  - 897-900
LID - 10.1016/j.urology.2008.01.024 [doi]
AB  - OBJECTIVES: Hyperhomocysteinemia (HHcy) is associated with cardiovascular disease 
      such as coronary arteriosclerosis and stroke. However, its role in the 
      development of vasculogenic erectile dysfunction (ED) is still putative. In this 
      study, we evaluated the relationship between plasma total homocysteine (tHcy) and 
      the presence of vasculogenic ED in men with adult-onset diabetes mellitus. 
      METHODS: This was a case-control study of 97 adult-onset diabetics with 
      vasculogenic ED and 97 concurrently sampled control diabetics, who were free from 
      ED. We obtained risk estimates of odds ratios (ORs), both crude and adjusted, 
      using logistic regression models. We then determined cardiovascular risk factors 
      and HbA1c levels in both groups of patients. RESULTS: Plasma tHcy was 
      significantly higher in cases compared with controls. The mean +/- standard 
      deviation plasma tHcy in cases was 11.2 +/- 3.5 micromol/L versus 8.8 +/- 2.6 
      micromol/L in controls (P <0.001). Moreover, those with HHcy had 5.2 times the 
      odds of vasculogenic ED compared with men without HHcy (OR 5.2, 95% confidence 
      interval, 1.4 to 18.9). Although the risk of ED did not vary significantly 
      according to body mass index, serum cholesterol, triglycerides, C-reactive 
      protein, and blood HbA1c levels, it was significantly affected by smoking status 
      and hypertension. CONCLUSIONS: High plasma tHcy appears to be associated with ED 
      in patient with adult-onset diabetes mellitus.
FAU - Al-Hunayan, Adel
AU  - Al-Hunayan A
AD  - Department of Surgery, Division of Urology, Kuwait University, Kuwait. 
      alhunayan@hsc.edu.kw
FAU - Thalib, Lukman
AU  - Thalib L
FAU - Kehinde, Elijah O
AU  - Kehinde EO
FAU - Asfar, Sami
AU  - Asfar S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Urology
JT  - Urology
JID - 0366151
SB  - IM
MH  - Case-Control Studies
MH  - Diabetes Complications/*complications
MH  - Humans
MH  - Hyperhomocysteinemia/*complications
MH  - Impotence, Vasculogenic/epidemiology/*etiology
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Risk Factors
EDAT- 2008/05/06 09:00
MHDA- 2008/06/03 09:00
CRDT- 2008/05/06 09:00
PHST- 2007/11/29 00:00 [received]
PHST- 2008/01/10 00:00 [revised]
PHST- 2008/01/11 00:00 [accepted]
PHST- 2008/05/06 09:00 [pubmed]
PHST- 2008/06/03 09:00 [medline]
PHST- 2008/05/06 09:00 [entrez]
AID - S0090-4295(08)00065-4 [pii]
AID - 10.1016/j.urology.2008.01.024 [doi]
PST - ppublish
SO  - Urology. 2008 May;71(5):897-900. doi: 10.1016/j.urology.2008.01.024.