PMID- 1845574
OWN - NLM
STAT- MEDLINE
DCOM- 19931007
LR  - 20131121
IS  - 1358-6173 (Print)
IS  - 1358-6173 (Linking)
VI  - 1
DP  - 1991
TI  - Genetic sensitivity to effect of ethanol on dopaminergic system in alcohol 
      preferring rats.
PG  - 439-42
AB  - The effect of ethanol (etOH) on dopamine (DA) metabolism in the caudate nucleus 
      (CN), olfactory tubercle (OT) and medial prefrontal cortex (MPFC) was compared in 
      2 selectively bred lines of rats, one etOH-preferring (sP) and the other -non 
      preferring (sNP). EtOH (2 g/kg per os), administered 60 min before killing, 
      caused a significant increase in concentrations of the DA metabolites 
      3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), and reduced 
      DA levels in CN and OT in sNP rats. On the other hand in sP rats, etOH increased 
      the content of DA metabolites in all the 3 areas analyzed. These changes induced 
      by etOH in DA metabolism were significantly greater in sP than in sNP rats. The 
      above data indicate that sP rats have a genetic high sensitivity to etOH effect 
      on DA metabolism probably linked to etOH preference.
FAU - Fadda, F
AU  - Fadda F
AD  - Department of Neurosciences, University of Cagliari, Italy.
FAU - Colombo, G
AU  - Colombo G
FAU - Gessa, G L
AU  - Gessa GL
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Alcohol Alcohol Suppl
JT  - Alcohol and alcoholism (Oxford, Oxfordshire). Supplement
JID - 8804836
RN  - 102-32-9 (3,4-Dihydroxyphenylacetic Acid)
RN  - 3K9958V90M (Ethanol)
RN  - VTD58H1Z2X (Dopamine)
RN  - X77S6GMS36 (Homovanillic Acid)
SB  - IM
MH  - 3,4-Dihydroxyphenylacetic Acid/metabolism
MH  - Alcoholism/genetics/*metabolism
MH  - Animals
MH  - Brain/drug effects/*metabolism
MH  - Caudate Nucleus/drug effects/metabolism
MH  - Dopamine/*metabolism
MH  - Ethanol/*pharmacology
MH  - Frontal Lobe/drug effects/metabolism
MH  - Homovanillic Acid/metabolism
MH  - Male
MH  - Olfactory Bulb/drug effects/metabolism
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Rats, Wistar
EDAT- 1991/01/01 00:00
MHDA- 1991/01/01 00:01
CRDT- 1991/01/01 00:00
PHST- 1991/01/01 00:00 [pubmed]
PHST- 1991/01/01 00:01 [medline]
PHST- 1991/01/01 00:00 [entrez]
PST - ppublish
SO  - Alcohol Alcohol Suppl. 1991;1:439-42.