PMID- 18455873
OWN - NLM
STAT- MEDLINE
DCOM- 20080919
LR  - 20151119
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 438
IP  - 2
DP  - 2008 Jun 20
TI  - Reduced expression of glyoxalase-1 mRNA in mood disorder patients.
PG  - 196-9
LID - 10.1016/j.neulet.2008.04.024 [doi]
AB  - Glyoxalase-1 (Glo1) is an antioxidant enzyme which detoxifies alpha-ketoaldehydes 
      to prevent the accumulation of pro-oxidant compounds, such as methylglyoxal, in 
      all cell types. Glo1 has been suggested to be involved in anxiety disorders, 
      autism, and Alzheimer's disease. Mood disorders have a high rate of comorbidity 
      with anxiety disorders although, to date, little is known of the involvement of 
      Glo1 in the pathophysiology of these conditions. In the present study, we 
      examined the expression levels of Glo1 mRNA in peripheral white blood cells of 
      mood disorder patients to understand the role of Glo1 in mood disorders. 
      Quantitative real-time polymerase chain reaction experiments revealed that 
      reduced expression of Glo1 mRNA was observed in major depressive and bipolar 
      disorder patients in a current depressive state, as compared with healthy control 
      subjects. In contrast, the expression of Glo1 mRNA in major depressive and 
      bipolar patients, in a remissive state, showed no significant alteration when 
      compared with healthy control subjects. These results suggest that the aberrant 
      expression of Glo1 might be involved in the pathophysiology of mood disorders.
FAU - Fujimoto, Michiko
AU  - Fujimoto M
AD  - Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University 
      Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755-8505, Japan.
FAU - Uchida, Shusaku
AU  - Uchida S
FAU - Watanuki, Toshio
AU  - Watanuki T
FAU - Wakabayashi, Yusuke
AU  - Wakabayashi Y
FAU - Otsuki, Koji
AU  - Otsuki K
FAU - Matsubara, Toshio
AU  - Matsubara T
FAU - Suetsugi, Masatomo
AU  - Suetsugi M
FAU - Funato, Hiromasa
AU  - Funato H
FAU - Watanabe, Yoshifumi
AU  - Watanabe Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080412
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Biomarkers)
RN  - 0 (RNA, Messenger)
RN  - EC 4.4.1.5 (Lactoylglutathione Lyase)
SB  - IM
MH  - Biomarkers/analysis/blood
MH  - Bipolar Disorder/enzymology/genetics/physiopathology
MH  - Brain/*enzymology/physiopathology
MH  - Brain Chemistry/*genetics
MH  - Depressive Disorder, Major/blood/enzymology/genetics
MH  - Down-Regulation/genetics
MH  - Female
MH  - Gene Expression Regulation, Enzymologic/genetics
MH  - Humans
MH  - Lactoylglutathione Lyase/*genetics
MH  - Leukocytes/*enzymology
MH  - Male
MH  - Middle Aged
MH  - Mood Disorders/blood/*enzymology/*genetics
MH  - RNA, Messenger/analysis/blood
MH  - Reverse Transcriptase Polymerase Chain Reaction
EDAT- 2008/05/06 09:00
MHDA- 2008/09/20 09:00
CRDT- 2008/05/06 09:00
PHST- 2007/09/17 00:00 [received]
PHST- 2008/04/09 00:00 [revised]
PHST- 2008/04/09 00:00 [accepted]
PHST- 2008/05/06 09:00 [pubmed]
PHST- 2008/09/20 09:00 [medline]
PHST- 2008/05/06 09:00 [entrez]
AID - S0304-3940(08)00499-0 [pii]
AID - 10.1016/j.neulet.2008.04.024 [doi]
PST - ppublish
SO  - Neurosci Lett. 2008 Jun 20;438(2):196-9. doi: 10.1016/j.neulet.2008.04.024. Epub 
      2008 Apr 12.