PMID- 18456675
OWN - NLM
STAT- MEDLINE
DCOM- 20080826
LR  - 20131121
IS  - 1933-7205 (Electronic)
IS  - 1933-7191 (Linking)
VI  - 15
IP  - 6
DP  - 2008 Jul
TI  - ECG and heart rate variability changes in preterm and near-term fetal lamb 
      following LPS exposure.
PG  - 572-83
LID - 10.1177/1933719107314060 [doi]
AB  - The aim of this study is to evaluate the myocardial response in the preterm and 
      near-term fetal lamb with infection. Chronically instrumented fetal lambs were 
      exposed to lipopolysaccharide (LPS), and the fetal electrocardiogram (FECG) ST 
      waveform was examined using STAN. Fetal heart rate variability (FHRV) was 
      automatically analyzed by adapting a polynomial function to the RR sequence in 
      the FECG. Preterm fetuses exposed to >90 ng/kg LPS died within 8 hours of LPS 
      administration, a response not seen in near-term fetuses. In both surviving and 
      nonsurviving preterm fetuses, cardiovascular responses were characterized by 
      decreased arterial pressure, negative T waves, and tachycardia accompanied by an 
      increase in FHRV. Similar changes were not observed in the near-term fetuses 
      after LPS. The study shows that preterm lambs are more sensitive to LPS in terms 
      of myocardial/cardiovascular response than the more mature fetuses are. High FHRV 
      and negative ST waveform seem to characterize the LPS-induced stress response in 
      preterm fetuses.
FAU - Blad, Sofia
AU  - Blad S
AD  - Perinatal Center, Department of Neuroscience and Physiology, Sahlgrenska Academy, 
      University of Gothenburg, Sweden. sofia.blad@gu.se
FAU - Welin, Anna-Karin
AU  - Welin AK
FAU - Kjellmer, Ingemar
AU  - Kjellmer I
FAU - Rosen, K G
AU  - Rosen KG
FAU - Mallard, Carina
AU  - Mallard C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080502
PL  - United States
TA  - Reprod Sci
JT  - Reproductive sciences (Thousand Oaks, Calif.)
JID - 101291249
RN  - 0 (Blood Glucose)
RN  - 0 (Lipopolysaccharides)
RN  - 33X04XA5AT (Lactic Acid)
SB  - IM
MH  - Animals
MH  - Blood Gas Analysis
MH  - Blood Glucose/analysis
MH  - Disease Models, Animal
MH  - Electrocardiography/*methods
MH  - Female
MH  - Fetal Monitoring/*methods
MH  - Fetus
MH  - Heart Rate, Fetal/*physiology
MH  - Lactic Acid/blood
MH  - Lipopolysaccharides/*pharmacology
MH  - Pregnancy
MH  - Sheep
MH  - Sheep Diseases/*microbiology/physiopathology
EDAT- 2008/05/06 09:00
MHDA- 2008/08/30 09:00
CRDT- 2008/05/06 09:00
PHST- 2008/05/06 09:00 [pubmed]
PHST- 2008/08/30 09:00 [medline]
PHST- 2008/05/06 09:00 [entrez]
AID - 1933719107314060 [pii]
AID - 10.1177/1933719107314060 [doi]
PST - ppublish
SO  - Reprod Sci. 2008 Jul;15(6):572-83. doi: 10.1177/1933719107314060. Epub 2008 May 
      2.