PMID- 18457263
OWN - NLM
STAT- MEDLINE
DCOM- 20091005
LR  - 20211203
IS  - 0253-2727 (Print)
IS  - 0253-2727 (Linking)
VI  - 28
IP  - 11
DP  - 2007 Nov
TI  - [Expression of CLLU1 in patients with chronic lymphocytic leukemia and its 
      prognostic significance].
PG  - 737-40
AB  - OBJECTIVE: To investigate CLLU1 expression and its relationship with clinical 
      stage, expression of CD38 and ZAP-70, and chromosome abnormalities in patients 
      with chronic lymphoid leukemia (CLL). METHODS: Fifty CLL patients were studied. 
      Semiquantitative RT-PCR was performed to detect CLLU1 expression levels; 
      three-color flow cytometry to detect the ZAP-70 and CD38 expression, interphase 
      fluorescence in situ hybridization (FISH) to detect chromosomal aberrations. 
      RESULTS: The expression of CLLU1 mRNA was detected in 26 of the 50 cases (52%), 
      of them 7 cases (26.92%) in Binet A and 19 (73. 08%) in Binet B + C. The 
      expression levels of CLLU1 were significantly higher in Binet stage B + C than in 
      Binet stage A (P < 0. 01). Among 24 CD38+ CLL cases, 17 (70. 83%) expressed high 
      CLLU1 mRNA, whereas in 26 CD38- CLL patients only 9 (34.62%) were CLLU1 positive. 
      The expression of CLLU1 in CD38+ CLL was significantly higher than that in CD38- 
      CLL (P < 0.05). However, no significant difference of CLLU1 expression was found 
      between ZAP-70+ and ZAP-70- patients (P > 0. 05), and between chromosomal 
      aberrations (P > 0. 05). CONCLUSIONS: CLLU1 expression was significantly 
      associated with clinical stage and CD38 expression, and might be an important 
      prognostic factor in CLL patients.
FAU - Chen, Li-Juan
AU  - Chen LJ
AD  - Department of Hematology, First Affiliated Hospital of Nanjing Medical 
      University, Jiangsu Province Hospital, Nanjing 210019, China.
FAU - Zheng, Wen-Juan
AU  - Zheng WJ
FAU - Wu, Yu-Jie
AU  - Wu YJ
FAU - Li, Li
AU  - Li L
FAU - Qian, Si-Xuan
AU  - Qian SX
FAU - Xu, Wei
AU  - Xu W
FAU - Li, Jian-Yong
AU  - Li JY
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Xue Ye Xue Za Zhi
JT  - Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
JID - 8212398
RN  - 0 (CLLU1 lncRNA, human)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (RNA, Long Noncoding)
RN  - EC 2.7.10.2 (ZAP-70 Protein-Tyrosine Kinase)
RN  - EC 2.7.10.2 (ZAP70 protein, human)
RN  - EC 3.2.2.6 (ADP-ribosyl Cyclase 1)
SB  - IM
MH  - ADP-ribosyl Cyclase 1/metabolism
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/genetics/*metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Proteins/*metabolism
MH  - Neoplasm Staging
MH  - Prognosis
MH  - RNA, Long Noncoding
MH  - ZAP-70 Protein-Tyrosine Kinase/metabolism
EDAT- 2008/05/07 09:00
MHDA- 2009/10/06 06:00
CRDT- 2008/05/07 09:00
PHST- 2008/05/07 09:00 [pubmed]
PHST- 2009/10/06 06:00 [medline]
PHST- 2008/05/07 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Xue Ye Xue Za Zhi. 2007 Nov;28(11):737-40.