PMID- 18457678
OWN - NLM
STAT- MEDLINE
DCOM- 20080826
LR  - 20220408
IS  - 0891-5849 (Print)
IS  - 0891-5849 (Linking)
VI  - 45
IP  - 3
DP  - 2008 Aug 1
TI  - Blueberry-induced changes in spatial working memory correlate with changes in 
      hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) 
      levels.
PG  - 295-305
LID - 10.1016/j.freeradbiomed.2008.04.008 [doi]
AB  - Phytochemical-rich foods have been shown to be effective at reversing age-related 
      deficits in memory in both animals and humans. We show that a supplementation 
      with a blueberry diet (2% w/w) for 12 weeks improves the performance of aged 
      animals in spatial working memory tasks. This improvement emerged within 3 weeks 
      and persisted for the remainder of the testing period. Memory performance 
      correlated well with the activation of cAMP-response element-binding protein 
      (CREB) and increases in both pro- and mature levels of brain-derived neurotrophic 
      factor (BDNF) in the hippocampus. Changes in CREB and BDNF in aged and 
      blueberry-supplemented animals were accompanied by increases in the 
      phosphorylation state of extracellular signal-related kinase (ERK1/2), rather 
      than that of calcium calmodulin kinase (CaMKII and CaMKIV) or protein kinase A. 
      Furthermore, age and blueberry supplementation were linked to changes in the 
      activation state of Akt, mTOR, and the levels of Arc/Arg3.1 in the hippocampus, 
      suggesting that pathways involved in de novo protein synthesis may be involved. 
      Although causal relationships cannot be made among supplementation, behavior, and 
      biochemical parameters, the measurement of anthocyanins and flavanols in the 
      brain following blueberry supplementation may indicate that changes in spatial 
      working memory in aged animals are linked to the effects of flavonoids on the 
      ERK-CREB-BDNF pathway.
FAU - Williams, Claire M
AU  - Williams CM
AD  - School of Psychology and Clinical Language Sciences, University of Reading, 
      Reading RG2 6AP, UK.
FAU - El Mohsen, Manal Abd
AU  - El Mohsen MA
FAU - Vauzour, David
AU  - Vauzour D
FAU - Rendeiro, Catarina
AU  - Rendeiro C
FAU - Butler, Laurie T
AU  - Butler LT
FAU - Ellis, Judi A
AU  - Ellis JA
FAU - Whiteman, Matthew
AU  - Whiteman M
FAU - Spencer, Jeremy P E
AU  - Spencer JP
LA  - eng
GR  - G0400278/MRC_/Medical Research Council/United Kingdom
GR  - BB/F008953/1/BB_/Biotechnology and Biological Sciences Research Council/United 
      Kingdom
GR  - BB/C518222/1/BB_/Biotechnology and Biological Sciences Research Council/United 
      Kingdom
GR  - G0400278/N102/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080505
PL  - United States
TA  - Free Radic Biol Med
JT  - Free radical biology & medicine
JID - 8709159
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 3)
SB  - IM
MH  - Animals
MH  - Blotting, Western
MH  - *Blueberry Plants
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cyclic AMP Response Element-Binding Protein/*metabolism
MH  - *Diet
MH  - Hippocampus/*physiology
MH  - Immunoassay
MH  - Male
MH  - Maze Learning/physiology
MH  - Memory/*physiology
MH  - Mitogen-Activated Protein Kinase 3/metabolism
MH  - Phosphorylation
MH  - Protein Kinases/metabolism
MH  - Proto-Oncogene Proteins c-akt/metabolism
MH  - Rats
MH  - TOR Serine-Threonine Kinases
EDAT- 2008/05/07 09:00
MHDA- 2008/08/30 09:00
CRDT- 2008/05/07 09:00
PHST- 2007/05/23 00:00 [received]
PHST- 2008/04/02 00:00 [revised]
PHST- 2008/04/07 00:00 [accepted]
PHST- 2008/05/07 09:00 [pubmed]
PHST- 2008/08/30 09:00 [medline]
PHST- 2008/05/07 09:00 [entrez]
AID - S0891-5849(08)00209-8 [pii]
AID - 10.1016/j.freeradbiomed.2008.04.008 [doi]
PST - ppublish
SO  - Free Radic Biol Med. 2008 Aug 1;45(3):295-305. doi: 
      10.1016/j.freeradbiomed.2008.04.008. Epub 2008 May 5.