PMID- 18459007
OWN - NLM
STAT- MEDLINE
DCOM- 20090129
LR  - 20220311
IS  - 1534-4681 (Electronic)
IS  - 1068-9265 (Linking)
VI  - 15
IP  - 11
DP  - 2008 Nov
TI  - A new scoring system for gallbladder cancer (aiding treatment algorithm): an 
      analysis of 335 patients.
PG  - 3132-7
LID - 10.1245/s10434-008-9917-y [doi]
AB  - BACKGROUND: There is currently no preoperative staging/scoring system available 
      for gallbladder cancer. Unfortunately, in gallbladder cancer, patients manifest 
      advanced stages of the disease. There is need for a methodology that can aid 
      accurate preoperative staging and the subsequent treatment algorithm. We thus 
      sought to validate a new scoring system, the Tata Memorial Hospital Staging 
      System (TMHSS), for gallbladder cancer. METHODS: TMHSS is based on the cumulative 
      impact of specific features of computed tomographic scan, presence or absence of 
      jaundice, and serum cancer antigen 19-9 levels. This scoring system was first 
      proposed in 2004. Patients with gallbladder cancer were enrolled onto the testing 
      sample for TMHSS to ascertain its validity. A total of 335 consecutive patients 
      with gallbladder cancer who sought care at the Tata Memorial Hospital between May 
      1, 2005, and December 31, 2006, were studied. Treatment was suggested on the 
      basis of current existing protocols. Each patient was assigned a TMHSS score, and 
      the treatment decision taken was compared with the algorithm generated for each 
      individual score. Concurrence of the decision taken with the score generated 
      algorithm was tested by the Kendall tau-b test. RESULTS: Ordinal-by-ordinal 
      analysis of the value of the test was .75, which showed excellent concurrence and 
      a statistically significant P value (P < .0001). CONCLUSION: TMHSS provides an 
      excellent correlative treatment plan for patients with gallbladder cancer. It has 
      the potential to reduce unnecessary surgical explorations and to direct patients 
      to the ideal treatment strategy, thereby offering a degree of prognostication.
FAU - Shukla, Parul J
AU  - Shukla PJ
AD  - Department of Gastrointestinal Surgical Oncology, Tata Memorial Hospital, Parel, 
      Mumbai 400 012, India. pjshukla@doctors.org.uk
FAU - Neve, Rakesh
AU  - Neve R
FAU - Barreto, Savio G
AU  - Barreto SG
FAU - Hawaldar, Rohini
AU  - Hawaldar R
FAU - Nadkarni, Mandar S
AU  - Nadkarni MS
FAU - Mohandas, K M
AU  - Mohandas KM
FAU - Shrikhande, Shailesh V
AU  - Shrikhande SV
LA  - eng
PT  - Journal Article
DEP - 20080506
PL  - United States
TA  - Ann Surg Oncol
JT  - Annals of surgical oncology
JID - 9420840
SB  - IM
CIN - Ann Surg Oncol. 2008 Nov;15(11):2991-2. PMID: 18709414
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Algorithms
MH  - Female
MH  - Gallbladder Neoplasms/*classification/*pathology/therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Survival Rate
MH  - Young Adult
EDAT- 2008/05/07 09:00
MHDA- 2009/01/30 09:00
CRDT- 2008/05/07 09:00
PHST- 2007/12/19 00:00 [received]
PHST- 2008/03/30 00:00 [accepted]
PHST- 2008/03/30 00:00 [revised]
PHST- 2008/05/07 09:00 [pubmed]
PHST- 2009/01/30 09:00 [medline]
PHST- 2008/05/07 09:00 [entrez]
AID - 10.1245/s10434-008-9917-y [doi]
PST - ppublish
SO  - Ann Surg Oncol. 2008 Nov;15(11):3132-7. doi: 10.1245/s10434-008-9917-y. Epub 2008 
      May 6.