PMID- 18460048
OWN - NLM
STAT- MEDLINE
DCOM- 20081113
LR  - 20221207
IS  - 0003-4800 (Print)
IS  - 1469-1809 (Electronic)
IS  - 0003-4800 (Linking)
VI  - 72
IP  - Pt 5
DP  - 2008 Sep
TI  - Genetic epidemiology of subclinical cardiovascular disease in the diabetes heart 
      study.
PG  - 598-610
LID - 10.1111/j.1469-1809.2008.00446.x [doi]
AB  - A genome-wide linkage scan of 357 European American (EA) and 72 African American 
      (AA) pedigrees multiplex for type 2 diabetes mellitus (T2DM) was performed with 
      multipoint nonparametric QTL linkage analysis. Four subclinical measures of 
      cardiovascular disease (CVD): coronary artery (CCP), carotid artery (CarCP), and 
      abdominal aortic calcified plaque (AACP) and carotid artery intima-media 
      thickness (IMT) were mapped. Analyses were adjusted for age, gender, body mass 
      index, and (if appropriate) ethnicity and diabetes status. Evidence for linkage 
      was observed in EA T2DM subjects to CarCP near 16p13 (LOD=4.39 at 8.4 cM; P = 
      0.00001). When all EA subjects were included, the LOD score was 2.52, suggesting 
      an amplification of the linkage by diabetes. Linkage analysis of a principal 
      components measure of vascular calcium (LOD = 3.85 at 9.3 cM on 16p in EA T2DM 
      subjects) and bivariate analysis of CarCP X IMT (LOD = 3.77 at 9.3 cM on 16p in 
      EA T2DM subjects) were consistent with this linkage. In addition, evidence for 
      linkage was observed with CCP near D15S1515 (LOD = 2.34) in EAs. Additional loci 
      on chromosomes 1, 2, 7, 10, 13, and 21 had LODs > 2.0. The identification of 
      trait-determining polymorphisms underlying these linkages will help delineate 
      risk factors for CVD in T2DM and the general population.
FAU - Bowden, D W
AU  - Bowden DW
AD  - Department of Biochemistry, Wake Forest University School of Medicine, 
      Winston-Salem, North Carolina, 27157, USA. dbowden@wfubmc.edu
FAU - Lehtinen, A B
AU  - Lehtinen AB
FAU - Ziegler, J T
AU  - Ziegler JT
FAU - Rudock, M E
AU  - Rudock ME
FAU - Xu, J
AU  - Xu J
FAU - Wagenknecht, L E
AU  - Wagenknecht LE
FAU - Herrington, D M
AU  - Herrington DM
FAU - Rich, S S
AU  - Rich SS
FAU - Freedman, B I
AU  - Freedman BI
FAU - Carr, J J
AU  - Carr JJ
FAU - Langefeld, C D
AU  - Langefeld CD
LA  - eng
GR  - R01 HL67348/HL/NHLBI NIH HHS/United States
GR  - R01 AR048797/AR/NIAMS NIH HHS/United States
GR  - R01 HL067348/HL/NHLBI NIH HHS/United States
GR  - M01 RR007122/RR/NCRR NIH HHS/United States
GR  - M01 RR07122/RR/NCRR NIH HHS/United States
GR  - R01 AR48797/AR/NIAMS NIH HHS/United States
GR  - N01HV48141/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20080429
PL  - England
TA  - Ann Hum Genet
JT  - Annals of human genetics
JID - 0416661
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Black or African American/genetics
MH  - Cardiovascular Diseases/complications/diagnostic imaging/epidemiology/*genetics
MH  - Coronary Artery Disease/complications/diagnostic imaging/epidemiology/genetics
MH  - DNA/genetics
MH  - Diabetes Mellitus, Type 2/complications/epidemiology/*genetics
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Lod Score
MH  - Male
MH  - Molecular Epidemiology
MH  - North Carolina/epidemiology
MH  - Pedigree
MH  - Quantitative Trait Loci
MH  - Tomography, X-Ray Computed
MH  - White People/genetics
PMC - PMC4890966
MID - NIHMS788218
EDAT- 2008/05/08 09:00
MHDA- 2008/11/14 09:00
PMCR- 2016/06/02
CRDT- 2008/05/08 09:00
PHST- 2008/05/08 09:00 [pubmed]
PHST- 2008/11/14 09:00 [medline]
PHST- 2008/05/08 09:00 [entrez]
PHST- 2016/06/02 00:00 [pmc-release]
AID - AHG446 [pii]
AID - 10.1111/j.1469-1809.2008.00446.x [doi]
PST - ppublish
SO  - Ann Hum Genet. 2008 Sep;72(Pt 5):598-610. doi: 10.1111/j.1469-1809.2008.00446.x. 
      Epub 2008 Apr 29.