PMID- 1846072
OWN - NLM
STAT- MEDLINE
DCOM- 19910208
LR  - 20190623
IS  - 0006-2952 (Print)
IS  - 0006-2952 (Linking)
VI  - 41
IP  - 1
DP  - 1991 Jan 1
TI  - Hydrogen peroxide modulation of the respiratory burst of human neutrophils.
PG  - 31-6
AB  - Addition of micromolar concentrations of hydrogen peroxide (H2O2) to human 
      neutrophils resulted in a dose-dependent luminol-enhanced chemiluminescent 
      response. Pretreatment of neutrophils with micromolar concentrations of H2O2 
      altered their response to the surface acting stimulants serum-treated zymosan 
      (STZ) and formyl-methionyl-leucyl-phenylalanine (fMLP), but not to the 
      intracellular stimulant phorbol myristate acetate (PMA). The alterations were 
      partially reversible by catalase, but exacerbated by superoxide dismutase. These 
      results suggest a modulatory role for H2O2 in the respiratory burst of 
      neutrophils.
FAU - Winn, J S
AU  - Winn JS
AD  - School of Biological Sciences, Macquarie University, North Ryde, NSW, Australia.
FAU - Guille, J
AU  - Guille J
FAU - Gebicki, J M
AU  - Gebicki JM
FAU - Day, R O
AU  - Day RO
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Biochem Pharmacol
JT  - Biochemical pharmacology
JID - 0101032
RN  - 59880-97-6 (N-Formylmethionine Leucyl-Phenylalanine)
RN  - 5EXP385Q4F (Luminol)
RN  - 9010-72-4 (Zymosan)
RN  - BBX060AN9V (Hydrogen Peroxide)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.11.1.7 (Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - NI40JAQ945 (Tetradecanoylphorbol Acetate)
SB  - IM
MH  - Catalase/pharmacology
MH  - Hydrogen Peroxide/antagonists & inhibitors/*pharmacology
MH  - Luminescent Measurements
MH  - Luminol
MH  - N-Formylmethionine Leucyl-Phenylalanine/pharmacology
MH  - Neutrophils/*drug effects/physiology
MH  - Peroxidase/*metabolism
MH  - Superoxide Dismutase/pharmacology
MH  - Tetradecanoylphorbol Acetate/pharmacology
MH  - Zymosan/pharmacology
EDAT- 1991/01/01 00:00
MHDA- 1991/01/01 00:01
CRDT- 1991/01/01 00:00
PHST- 1991/01/01 00:00 [pubmed]
PHST- 1991/01/01 00:01 [medline]
PHST- 1991/01/01 00:00 [entrez]
AID - 0006-2952(91)90007-R [pii]
AID - 10.1016/0006-2952(91)90007-r [doi]
PST - ppublish
SO  - Biochem Pharmacol. 1991 Jan 1;41(1):31-6. doi: 10.1016/0006-2952(91)90007-r.