PMID- 18461095
OWN - NLM
STAT- MEDLINE
DCOM- 20081124
LR  - 20160513
IS  - 1715-5312 (Print)
IS  - 1715-5312 (Linking)
VI  - 33
IP  - 3
DP  - 2008 Jun
TI  - Assessment of exercise capacity and respiratory muscle oxygenation in healthy 
      children and children with congenital heart diseases.
PG  - 434-40
LID - 10.1139/H07-196 [doi]
AB  - Muscular and cardiorespiratory dysfunction contributes to exercise intolerance. 
      Therefore, the aim of the present study was to characterize the cardiopulmonary 
      response andrespiratory muscle oxygenation of children with congenital heart 
      diseases (CHD) when compared with those of healthy children. Twelve children with 
      CHD in New York Heart Association (NYHA) class II or III, and 14 healthy children 
      participated in the study. All subjects performed conventional spirographic 
      measurements and a cardiopulmonary exercise test on a cycle ergometer. Oxygen 
      uptake (VO(2)), carbon dioxide production (VCO(2)), minute ventilation (VE), 
      heart rate (HR), and power output were measured. Oxygenation of respiratory 
      muscles was assessed by near-infrared spectroscopy (NIRS) during exercise and 
      recovery. Pulmonary function was normal and no significant difference was found 
      between groups. At rest, CHD patients had cardiorespiratory variables comparable 
      with those of the healthy group. At submaximal intensity (ventilatory threshold) 
      and at peak exercise, power output, HR, VO(2), VCO(2), and VE were significantly 
      reduced (p < 0.01) in CHD patients. Respiratory muscles deoxygenated during 
      exercise in both groups. However, deoxygenation was more pronounced in the CHD 
      group than in the healthy children from an intensity of 40% up to exhaustion. 
      Likewise, children with CHD showed a slower recovery of oxygenation than healthy 
      children (113.4 +/- 17.5 vs. 74.6 +/- 13.0 s; p < 0.001). Compared with healthy 
      children, these results demonstrated that children with CHD have reduced 
      performance and present a defected exercise capacity. Children with CHD showed a 
      more pronounced decrease of respiratory muscle oxygenation and slower recovery of 
      oxygen kinetics.
FAU - Moalla, Wassim
AU  - Moalla W
AD  - Faculte des sciences du sport, Universite de Picardie, Amiens, France. 
      wassim.moalla@gmail.com
FAU - Dupont, Gregory
AU  - Dupont G
FAU - Temfemo, Abdou
AU  - Temfemo A
FAU - Maingourd, Yves
AU  - Maingourd Y
FAU - Weston, Matthew
AU  - Weston M
FAU - Ahmaidi, Said
AU  - Ahmaidi S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Canada
TA  - Appl Physiol Nutr Metab
JT  - Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition 
      et metabolisme
JID - 101264333
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Cross-Sectional Studies
MH  - Exercise/*physiology
MH  - Exercise Test
MH  - Heart Defects, Congenital/*physiopathology
MH  - Heart Rate/physiology
MH  - Humans
MH  - Oxygen Consumption/*physiology
MH  - Respiratory Muscles/*physiology
MH  - Spectroscopy, Near-Infrared
MH  - Spirometry
MH  - Vital Capacity
EDAT- 2008/05/08 09:00
MHDA- 2008/12/17 09:00
CRDT- 2008/05/08 09:00
PHST- 2008/05/08 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/05/08 09:00 [entrez]
AID - h07-196 [pii]
AID - 10.1139/H07-196 [doi]
PST - ppublish
SO  - Appl Physiol Nutr Metab. 2008 Jun;33(3):434-40. doi: 10.1139/H07-196.