PMID- 18463262
OWN - NLM
STAT- MEDLINE
DCOM- 20080613
LR  - 20220223
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 28
IP  - 19
DP  - 2008 May 7
TI  - Dorsomedial prefrontal cortex contribution to behavioral and nucleus accumbens 
      neuronal responses to incentive cues.
PG  - 5088-98
LID - 10.1523/JNEUROSCI.0253-08.2008 [doi]
AB  - Cue-elicited phasic changes in firing of nucleus accumbens (NAc) neurons can 
      facilitate reward-seeking behavior. Here, we test the hypothesis that the medial 
      prefrontal cortex (mPFC), which sends a dense glutamatergic projection to the NAc 
      core, contributes to NAc neuronal firing responses to reward-predictive cues. 
      Rats trained to perform an operant response to a cue for sucrose were implanted 
      with recording electrodes in the core of the NAc and microinjection cannulas in 
      the dorsal mPFC (dmPFC). The cue-evoked firing of NAc neurons was reduced by 
      bilateral injection of GABA(A) and GABA(B) agonists into the dmPFC concomitant 
      with loss of behavioral responding to the cue. In addition, unilateral dmPFC 
      inactivation reduced ipsilateral cue excitations and contralateral cue 
      inhibitions. These findings indicate that cue-evoked excitations and inhibitions 
      of NAc core neurons depend on dmPFC projections to the NAc and that these phasic 
      changes contribute to the behavioral response to reward-predictive cues.
FAU - Ishikawa, Akinori
AU  - Ishikawa A
AD  - Ernest Gallo Clinic and Research Center and Department of Neurology, University 
      of California, San Francisco, Emeryville, California 94608, USA. 
      akinori@yamaguchi-u.ac.jp
FAU - Ambroggi, Frederic
AU  - Ambroggi F
FAU - Nicola, Saleem M
AU  - Nicola SM
FAU - Fields, Howard L
AU  - Fields HL
LA  - eng
GR  - R01 DA019473/DA/NIDA NIH HHS/United States
GR  - R01 DA019473-04/DA/NIDA NIH HHS/United States
GR  - DA019473/DA/NIDA NIH HHS/United States
GR  - R01 DA019473-01A1/DA/NIDA NIH HHS/United States
GR  - R01 DA019473-02/DA/NIDA NIH HHS/United States
GR  - R01 DA019473-03/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (GABA Agonists)
RN  - 0 (GABA-A Receptor Agonists)
RN  - 0 (GABA-B Receptor Agonists)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/*physiology
MH  - *Cues
MH  - Electrophysiology
MH  - GABA Agonists/administration & dosage/pharmacology
MH  - GABA-A Receptor Agonists
MH  - GABA-B Receptor Agonists
MH  - Male
MH  - Microinjections
MH  - *Motivation
MH  - Neural Inhibition/physiology
MH  - Neurons/*physiology
MH  - Nucleus Accumbens/*physiology
MH  - Prefrontal Cortex/*physiology
MH  - Rats
MH  - Rats, Long-Evans
MH  - Reward
MH  - Synaptic Transmission/physiology
PMC - PMC2661106
MID - NIHMS83452
EDAT- 2008/05/09 09:00
MHDA- 2008/06/14 09:00
PMCR- 2008/11/07
CRDT- 2008/05/09 09:00
PHST- 2008/05/09 09:00 [pubmed]
PHST- 2008/06/14 09:00 [medline]
PHST- 2008/05/09 09:00 [entrez]
PHST- 2008/11/07 00:00 [pmc-release]
AID - 28/19/5088 [pii]
AID - 3349678 [pii]
AID - 10.1523/JNEUROSCI.0253-08.2008 [doi]
PST - ppublish
SO  - J Neurosci. 2008 May 7;28(19):5088-98. doi: 10.1523/JNEUROSCI.0253-08.2008.