PMID- 18463397
OWN - NLM
STAT- MEDLINE
DCOM- 20080624
LR  - 20211020
IS  - 1538-7445 (Electronic)
IS  - 0008-5472 (Print)
IS  - 0008-5472 (Linking)
VI  - 68
IP  - 10
DP  - 2008 May 15
TI  - Hoxb7 inhibits transgenic HER-2/neu-induced mouse mammary tumor onset but 
      promotes progression and lung metastasis.
PG  - 3637-44
LID - 10.1158/0008-5472.CAN-07-2926 [doi]
AB  - Our previous studies have shown that HOXB7 mRNA is overexpressed in approximately 
      50% of invasive breast carcinomas and promotes tumor progression in breast cancer 
      cells grown as xenografts in mice. In silico analysis of published microarray 
      data showed that high levels of HOXB7 predict a poor outcome in HER-2-positive (P 
      = 0.046), but not in HER-2-negative breast cancers (P = 0.94). To study the 
      function of HOXB7 in vivo in the context of HER-2 overexpression, we generated 
      mouse mammary tumor virus (MMTV)-Hoxb7 transgenic mice, and then crossed them 
      with MMTV-HER-2/neu transgenic mice. In the mice carrying both Hoxb7 and 
      HER-2/neu transgenes, Hoxb7 plays a dual role in mammary tumorigenesis. In double 
      transgenic mice, overexpression of Hoxb7 delayed tumor onset and lowered tumor 
      multiplicity. However, consistent with the clinical data, once the tumors 
      appeared, their growth was faster and metastasis to the lungs occurred at a 
      higher frequency. Our data show, for the first time, that deregulated expression 
      of Hoxb7 in mammary tumor cells can significantly modulate HER-2/neu-oncogene 
      induced tumorigenesis in vivo.
FAU - Chen, Hexin
AU  - Chen H
AD  - The Breast Cancer Program, Sidney Kimmel Comprehensive Cancer Center at Johns 
      Hopkins, Baltimore, Maryland, USA.
FAU - Lee, Ji Shin
AU  - Lee JS
FAU - Liang, Xiaohui
AU  - Liang X
FAU - Zhang, Huiping
AU  - Zhang H
FAU - Zhu, Tao
AU  - Zhu T
FAU - Zhang, Zhe
AU  - Zhang Z
FAU - Taylor, M Evangeline
AU  - Taylor ME
FAU - Zahnow, Cynthia
AU  - Zahnow C
FAU - Feigenbaum, Lionel
AU  - Feigenbaum L
FAU - Rein, Alan
AU  - Rein A
FAU - Sukumar, Saraswati
AU  - Sukumar S
LA  - eng
GR  - P50 CA088843/CA/NCI NIH HHS/United States
GR  - P50 CA88843/CA/NCI NIH HHS/United States
GR  - ImNIH/Intramural NIH HHS/United States
GR  - N01CO12400/CA/NCI NIH HHS/United States
GR  - N01-CO-12400/CO/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20080507
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Hoxb7 protein, mouse)
RN  - EC 2.7.10.1 (Receptor, ErbB-2)
SB  - IM
MH  - Alleles
MH  - Animals
MH  - Apoptosis
MH  - Cell Proliferation
MH  - Disease Progression
MH  - Homeodomain Proteins/*genetics/*physiology
MH  - Lung Neoplasms/*pathology/*secondary
MH  - Mammary Neoplasms, Animal/*genetics/pathology/*therapy
MH  - Mice
MH  - Neoplasm Metastasis
MH  - Neovascularization, Pathologic
MH  - Oligonucleotide Array Sequence Analysis
MH  - Phenotype
MH  - Receptor, ErbB-2/*genetics
MH  - Treatment Outcome
PMC - PMC3715065
MID - NIHMS485968
COIS- Disclosure of Potential Conflicts of Interest No potential conflicts of interest 
      were disclosed.
EDAT- 2008/05/09 09:00
MHDA- 2008/06/25 09:00
PMCR- 2013/07/18
CRDT- 2008/05/09 09:00
PHST- 2008/05/09 09:00 [pubmed]
PHST- 2008/06/25 09:00 [medline]
PHST- 2008/05/09 09:00 [entrez]
PHST- 2013/07/18 00:00 [pmc-release]
AID - 0008-5472.CAN-07-2926 [pii]
AID - 10.1158/0008-5472.CAN-07-2926 [doi]
PST - ppublish
SO  - Cancer Res. 2008 May 15;68(10):3637-44. doi: 10.1158/0008-5472.CAN-07-2926. Epub 
      2008 May 7.