PMID- 1846608
OWN - NLM
STAT- MEDLINE
DCOM- 19910307
LR  - 20210210
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 266
IP  - 4
DP  - 1991 Feb 5
TI  - Interleukin-6 induces the synthesis of tissue inhibitor of 
      metalloproteinases-1/erythroid potentiating activity (TIMP-1/EPA).
PG  - 2017-20
AB  - This study examines the role of interleukin-6 (IL-6) in connective tissue 
      metabolism. Effects of different preparations of IL-6 on production of 
      collagenase and tissue inhibitor of metalloproteinases-1/erythroid potentiating 
      activity production are studied in human fibroblasts, synoviocytes, and articular 
      chondrocytes. In contrast to interleukin-1 beta (IL-1 beta) and tumor necrosis 
      factor-alpha (TNF alpha), IL-6 does not stimulate the production of collagenase, 
      nor does it modulate the stimulatory effects of IL-1 beta and TNF alpha on the 
      production of this proteinase. Furthermore, IL-6 has no detectable effect on 
      prostaglandin E2 production, an additional proinflammatory response induced by 
      IL-1 beta and TNF alpha. IL-6, however, is identified as a potent inducer of de 
      novo synthesis of tissue inhibitor of metalloproteinases-1/erythroid potentiating 
      activity in all types of connective tissue cells examined. These results define 
      new biological activities of IL-6 and provide further insight into the regulation 
      of connective tissues by cytokines.
FAU - Lotz, M
AU  - Lotz M
AD  - Department of Medicine, University of California, San Diego, La Jolla 92093.
FAU - Guerne, P A
AU  - Guerne PA
LA  - eng
GR  - AG07996/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (Glycoproteins)
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-6)
RN  - 0 (Lymphokines)
RN  - 0 (Tissue Inhibitor of Metalloproteinases)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 3.4.24.- (Metalloendopeptidases)
RN  - EC 3.4.24.3 (Microbial Collagenase)
RN  - K7Q1JQR04M (Dinoprostone)
SB  - IM
MH  - Cartilage, Articular/cytology/*metabolism
MH  - Dinoprostone/metabolism
MH  - Fibroblasts/*metabolism
MH  - Glycoproteins/*biosynthesis
MH  - Humans
MH  - Interleukin-1/pharmacology
MH  - Interleukin-6/*pharmacology
MH  - Lymphokines/biosynthesis
MH  - Metalloendopeptidases/*antagonists & inhibitors
MH  - Microbial Collagenase/metabolism
MH  - Synovial Fluid/cytology/*metabolism
MH  - Tissue Inhibitor of Metalloproteinases
MH  - Tumor Necrosis Factor-alpha/pharmacology
EDAT- 1991/02/05 00:00
MHDA- 1991/02/05 00:01
CRDT- 1991/02/05 00:00
PHST- 1991/02/05 00:00 [pubmed]
PHST- 1991/02/05 00:01 [medline]
PHST- 1991/02/05 00:00 [entrez]
AID - S0021-9258(18)52202-X [pii]
PST - ppublish
SO  - J Biol Chem. 1991 Feb 5;266(4):2017-20.