PMID- 18466328
OWN - NLM
STAT- MEDLINE
DCOM- 20080915
LR  - 20220330
IS  - 1471-4159 (Electronic)
IS  - 0022-3042 (Linking)
VI  - 106
IP  - 3
DP  - 2008 Aug
TI  - Extracellular levels of brain aspartate, glutamate and GABA during an inhibitory 
      avoidance response in the rat.
PG  - 1035-43
LID - 10.1111/j.1471-4159.2008.05452.x [doi]
AB  - The extracellular levels of aspartate, glutamate and GABA were measured by 
      microdialysis, coupled with an HPLC method, in rat prefrontal cortex (mPFC) and 
      ventral hippocampus (VH) before and during the performance of a step-down 
      inhibitory task. The basal levels of glutamate were about 50% higher than those 
      of aspartate, and GABA levels were about 20-folds smaller than those of the 
      excitatory amino acids. There were no significant differences in the basal levels 
      of any of the three amino acids between the two brain regions. The extracellular 
      levels of aspartate increased during acquisition and recall trials in both VH and 
      mPFC, whereas those of glutamate increased in the VH during acquisition only. A 
      significant increase in GABA levels was also detected during acquisition but only 
      in the mPFC. The neuronal origin of the increased extracellular levels of 
      aspartate, glutamate and GABA was demonstrated by administering tetrodotoxin 
      directly into the mPFC or VH by reverse dialysis. These findings, together with 
      previous evidence from our and other laboratories, indicate a differential 
      release of aspartate and glutamate from excitatory neurons during the performance 
      of behavioral responses, and therefore, distinct roles for the two excitatory 
      amino acids should be envisaged.
FAU - Ballini, Chiara
AU  - Ballini C
AD  - Dipartimento di Farmacologia Preclinica e Clinica M. Aiazzi Mancini, Universita 
      degli Studi di Firenze, Viale G. Pieraccini, Firenze, Italia.
FAU - Corte, Laura Della
AU  - Corte LD
FAU - Pazzagli, Marta
AU  - Pazzagli M
FAU - Colivicchi, Maria Alessandra
AU  - Colivicchi MA
FAU - Pepeu, Giancarlo
AU  - Pepeu G
FAU - Tipton, Keith F
AU  - Tipton KF
FAU - Giovannini, Maria Grazia
AU  - Giovannini MG
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080503
PL  - England
TA  - J Neurochem
JT  - Journal of neurochemistry
JID - 2985190R
RN  - 30KYC7MIAI (Aspartic Acid)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
SB  - IM
MH  - Animals
MH  - Aspartic Acid/analysis/*metabolism
MH  - Avoidance Learning/*physiology
MH  - Extracellular Space/chemistry/*metabolism
MH  - Glutamic Acid/analysis/*metabolism
MH  - Male
MH  - Neural Inhibition/*physiology
MH  - Rats
MH  - Rats, Wistar
MH  - gamma-Aminobutyric Acid/analysis/*metabolism
EDAT- 2008/05/10 09:00
MHDA- 2008/09/16 09:00
CRDT- 2008/05/10 09:00
PHST- 2008/05/10 09:00 [pubmed]
PHST- 2008/09/16 09:00 [medline]
PHST- 2008/05/10 09:00 [entrez]
AID - JNC5452 [pii]
AID - 10.1111/j.1471-4159.2008.05452.x [doi]
PST - ppublish
SO  - J Neurochem. 2008 Aug;106(3):1035-43. doi: 10.1111/j.1471-4159.2008.05452.x. Epub 
      2008 May 3.