PMID- 1846645 OWN - NLM STAT- MEDLINE DCOM- 19910305 LR - 20061115 IS - 0022-1317 (Print) IS - 0022-1317 (Linking) VI - 72 ( Pt 1) DP - 1991 Jan TI - Physicochemical characterization of human herpesvirus 6 infectivity. PG - 169-72 AB - Infectivity of human herpesvirus 6 (HHV-6) was physicochemically characterized. Virus particles were excreted from infected cord blood mononuclear cells into the culture supernatant at a concentration of 10(8) to 10(9) virus particles/ml. The virus particle/infectivity ratio of HHV-6 in the culture supernatant was approximately 10(3):1 and that in the sonicated infected cells was 10(4):1. Infectivity was stable below 37 degrees C and at neutral pH (7.0 to 8.5). These fundamental data may be useful for serological and biological research on HHV-6. FAU - Shiraki, K AU - Shiraki K AD - Department of Virology, Osaka University, Japan. FAU - Mukai, T AU - Mukai T FAU - Okuno, T AU - Okuno T FAU - Yamanishi, K AU - Yamanishi K FAU - Takahashi, M AU - Takahashi M LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - J Gen Virol JT - The Journal of general virology JID - 0077340 SB - IM MH - Cells, Cultured MH - Herpesvirus 6, Human/*growth & development/physiology/ultrastructure MH - Humans MH - Leukocytes, Mononuclear MH - Microscopy, Electron MH - Temperature EDAT- 1991/01/01 00:00 MHDA- 1991/01/01 00:01 CRDT- 1991/01/01 00:00 PHST- 1991/01/01 00:00 [pubmed] PHST- 1991/01/01 00:01 [medline] PHST- 1991/01/01 00:00 [entrez] AID - 10.1099/0022-1317-72-1-169 [doi] PST - ppublish SO - J Gen Virol. 1991 Jan;72 ( Pt 1):169-72. doi: 10.1099/0022-1317-72-1-169.