PMID- 18467525
OWN - NLM
STAT- MEDLINE
DCOM- 20080903
LR  - 20211020
IS  - 0888-8809 (Print)
IS  - 0888-8809 (Linking)
VI  - 22
IP  - 7
DP  - 2008 Jul
TI  - CCAAT/enhancer binding protein-beta is a transcriptional regulator of 
      peroxisome-proliferator-activated receptor-gamma coactivator-1alpha in the 
      regenerating liver.
PG  - 1596-605
LID - 10.1210/me.2007-0388 [doi]
AB  - The transcriptional coactivator peroxisome-proliferator-activated receptor-gamma 
      coactivator-1alpha (PGC-1alpha) is induced in the liver in response to fasting 
      and coordinates the activation of targets necessary for increasing energy 
      production for gluconeogenesis and ketogenesis. After partial hepatectomy, the 
      liver must restore its mass while maintaining metabolic homeostasis to ensure 
      survival. Here we report that PGC-1alpha is rapidly and dramatically induced 
      after hepatectomy, with an amplitude of induction that exceeds the fasting 
      response. Maximal activation of PGC-1alpha after hepatectomy is dependent on the 
      basic leucine zipper transcription factor, CCAAT/enhancer binding protein-beta 
      (C/EBPbeta), a critical factor in hepatocyte proliferation. We demonstrate in 
      vivo C/EBPbeta binding to C/EBP and cAMP response element sites in the PGC-1alpha 
      promoter and show that the C/EBP site is essential for PGC-1alpha activation. 
      Expression of the PGC-1alpha target, carnitine palmitoyl transferase 1a, the 
      rate-limiting enzyme in fatty acid beta-oxidation, and of long-chain 
      acyl-coenzyme A dehydrogenase, an enzyme involved in beta-oxidation of long chain 
      fatty acids, was significantly reduced in C/EBPbeta(-/-) livers after 
      hepatectomy. These findings identify C/EBPbeta as a direct activator of 
      PGC-1alpha in the regenerating liver. The demonstration of a functional link 
      between C/EBPbeta and PGC-1alpha activation provides a likely mechanism for how 
      upstream signaling pathways in the regenerating liver can enable the adaptation 
      to the changed metabolic status.
FAU - Wang, Haitao
AU  - Wang H
AD  - Department of Medicine, University of Pennsylvania School of Medicine, 
      Philadelphia, PA 19104, USA.
FAU - Peiris, T Harshani
AU  - Peiris TH
FAU - Mowery, A
AU  - Mowery A
FAU - Le Lay, John
AU  - Le Lay J
FAU - Gao, Yan
AU  - Gao Y
FAU - Greenbaum, Linda E
AU  - Greenbaum LE
LA  - eng
GR  - R01 DK056669/DK/NIDDK NIH HHS/United States
GR  - R01 DK 056669/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20080508
PL  - United States
TA  - Mol Endocrinol
JT  - Molecular endocrinology (Baltimore, Md.)
JID - 8801431
RN  - 0 (CCAAT-Enhancer-Binding Protein-beta)
RN  - 0 (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha)
RN  - 0 (Ppargc1a protein, mouse)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
RN  - IY9XDZ35W2 (Glucose)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Animals
MH  - Binding Sites
MH  - CCAAT-Enhancer-Binding Protein-beta/*metabolism
MH  - Cell Line
MH  - Cricetinae
MH  - Glucose/metabolism
MH  - Homozygote
MH  - Humans
MH  - Liver/*metabolism
MH  - *Liver Regeneration
MH  - Mice
MH  - Oxygen/chemistry
MH  - Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
MH  - Trans-Activators/*metabolism
MH  - Transcription Factors/metabolism
MH  - *Transcription, Genetic
PMC - PMC2453599
EDAT- 2008/05/10 09:00
MHDA- 2008/09/04 09:00
PMCR- 2009/07/01
CRDT- 2008/05/10 09:00
PHST- 2008/05/10 09:00 [pubmed]
PHST- 2008/09/04 09:00 [medline]
PHST- 2008/05/10 09:00 [entrez]
PHST- 2009/07/01 00:00 [pmc-release]
AID - me.2007-0388 [pii]
AID - 4295 [pii]
AID - 10.1210/me.2007-0388 [doi]
PST - ppublish
SO  - Mol Endocrinol. 2008 Jul;22(7):1596-605. doi: 10.1210/me.2007-0388. Epub 2008 May 
      8.