PMID- 18467543
OWN - NLM
STAT- MEDLINE
DCOM- 20080903
LR  - 20131121
IS  - 8750-7587 (Print)
IS  - 0161-7567 (Linking)
VI  - 105
IP  - 1
DP  - 2008 Jul
TI  - High rates of muscle glycogen resynthesis after exhaustive exercise when 
      carbohydrate is coingested with caffeine.
PG  - 7-13
LID - 10.1152/japplphysiol.01121.2007 [doi]
AB  - We determined the effect of coingestion of caffeine (Caff) with carbohydrate 
      (CHO) on rates of muscle glycogen resynthesis during recovery from exhaustive 
      exercise in seven trained subjects who completed two experimental trials in a 
      randomized, double-blind crossover design. The evening before an experiment 
      subjects performed intermittent exhaustive cycling and then consumed a low-CHO 
      meal. The next morning subjects rode until volitional fatigue. On completion of 
      this ride subjects consumed either CHO [4 g/kg body mass (BM)] or the same amount 
      of CHO + Caff (8 mg/kg BM) during 4 h of passive recovery. Muscle biopsies and 
      blood samples were taken at regular intervals throughout recovery. Muscle 
      glycogen levels were similar at exhaustion [ approximately 75 mmol/kg dry wt 
      (dw)] and increased by a similar amount ( approximately 80%) after 1 h of 
      recovery (133 +/- 37.8 vs. 149 +/- 48 mmol/kg dw for CHO and Caff, respectively). 
      After 4 h of recovery Caff resulted in higher glycogen accumulation (313 +/- 69 
      vs. 234 +/- 50 mmol/kg dw, P < 0.001). Accordingly, the overall rate of 
      resynthesis for the 4-h recovery period was 66% higher in Caff compared with CHO 
      (57.7 +/- 18.5 vs. 38.0 +/- 7.7 mmol x kg dw(-1) x h(-1), P < 0.05). After 1 h of 
      recovery plasma Caff levels had increased to 31 +/- 11 microM (P < 0.001) and at 
      the end of the recovery reached 77 +/- 11 microM (P < 0.001) with Caff. 
      Phosphorylation of CaMK(Thr286) was similar after exercise and after 1 h of 
      recovery, but after 4 h CaMK(Thr286) phosphorylation was higher in Caff than CHO 
      (P < 0.05). Phosphorylation of AMP-activated protein kinase (AMPK)(Thr172) and 
      Akt(Ser473) was similar for both treatments at all time points. We provide the 
      first evidence that in trained subjects coingestion of large amounts of Caff (8 
      mg/kg BM) with CHO has an additive effect on rates of postexercise muscle 
      glycogen accumulation compared with consumption of CHO alone.
FAU - Pedersen, David J
AU  - Pedersen DJ
AD  - School of Medical Sciences, RMIT University, Bundoora 3083, Victoria, Australia.
FAU - Lessard, Sarah J
AU  - Lessard SJ
FAU - Coffey, Vernon G
AU  - Coffey VG
FAU - Churchley, Emmanuel G
AU  - Churchley EG
FAU - Wootton, Andrew M
AU  - Wootton AM
FAU - Ng, They
AU  - Ng T
FAU - Watt, Matthew J
AU  - Watt MJ
FAU - Hawley, John A
AU  - Hawley JA
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20080508
PL  - United States
TA  - J Appl Physiol (1985)
JT  - Journal of applied physiology (Bethesda, Md. : 1985)
JID - 8502536
RN  - 0 (Blood Glucose)
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Insulin)
RN  - 3G6A5W338E (Caffeine)
RN  - 9005-79-2 (Glycogen)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.11.1 (Oncogene Protein v-akt)
RN  - EC 2.7.11.11 (Cyclic AMP-Dependent Protein Kinases)
SB  - IM
MH  - Adult
MH  - Anaerobic Threshold/physiology
MH  - Bicycling/physiology
MH  - Blood Glucose/metabolism
MH  - Blotting, Western
MH  - Caffeine/blood/*pharmacology
MH  - Central Nervous System Stimulants/blood/*pharmacology
MH  - Cross-Over Studies
MH  - Cyclic AMP-Dependent Protein Kinases/metabolism
MH  - Diet
MH  - Dietary Carbohydrates/*pharmacology
MH  - Double-Blind Method
MH  - Exercise/*physiology
MH  - Exercise Test
MH  - Glycogen/*biosynthesis
MH  - Humans
MH  - Insulin/blood
MH  - Kinetics
MH  - Male
MH  - Muscle, Skeletal/drug effects/*metabolism
MH  - Oncogene Protein v-akt/metabolism
MH  - Protein Kinases/metabolism
MH  - Signal Transduction/drug effects/physiology
EDAT- 2008/05/10 09:00
MHDA- 2008/09/04 09:00
CRDT- 2008/05/10 09:00
PHST- 2008/05/10 09:00 [pubmed]
PHST- 2008/09/04 09:00 [medline]
PHST- 2008/05/10 09:00 [entrez]
AID - 01121.2007 [pii]
AID - 10.1152/japplphysiol.01121.2007 [doi]
PST - ppublish
SO  - J Appl Physiol (1985). 2008 Jul;105(1):7-13. doi: 
      10.1152/japplphysiol.01121.2007. Epub 2008 May 8.