PMID- 18467683
OWN - NLM
STAT- MEDLINE
DCOM- 20081020
LR  - 20231213
IS  - 1533-1601 (Electronic)
IS  - 0192-6233 (Linking)
VI  - 36
IP  - 4
DP  - 2008 Jun
TI  - Ursolic acid and oleanolic acid suppress preneoplastic lesions induced by 
      1,2-dimethylhydrazine in rat colon.
PG  - 576-80
LID - 10.1177/0192623308317423 [doi]
AB  - Ursolic acid (UA) and oleanolic acid (OA) are pentacyclic triterpenoid compounds 
      found in plants used in the human diet and in medicinal herbs, in the form of 
      aglycones or as the free acid. These compounds are known for their 
      hepatoprotective, anti-inflammatory, antimicrobial, hypoglycemic, antimutagenic, 
      antioxidant, and antifertility activities. In the present study, we evaluated the 
      effects of UA and OA on the formation of 1,2-dimethyl-hydrazine (DMH)-induced 
      aberrant crypt foci (ACF) in the colon of the male Wistar rat. The animals 
      received subcutaneous (sc) injections of DMH (40 mg/kg body weight) twice a week 
      for two weeks to induce ACF. UA, OA and a mixture of UA and OA were administered 
      to the rats five times a week for four weeks by gavage at doses of 25 mg/kg body 
      weight/day each, during and after DMH treatment. All animals were sacrificed in 
      week 5 for the evaluation of ACF. The results showed a significant reduction in 
      the frequency of ACF in the group treated with the triterpenoid compounds plus 
      DMH when compared to those treated with DMH alone, suggesting that UA and OA 
      suppress the formation of ACF and have a protective effect against colon 
      carcinogenesis.
FAU - Furtado, Ricardo A
AU  - Furtado RA
AD  - Universidade de Franca, Avenida Dr. Armando Salles de Oliveira, 201 Parque 
      Universitario, Franca-SP, Brazil.
FAU - Rodrigues, Erlon P
AU  - Rodrigues EP
FAU - Araujo, Felipe R R
AU  - Araujo FR
FAU - Oliveira, Wendel L
AU  - Oliveira WL
FAU - Furtado, Michelle A
AU  - Furtado MA
FAU - Castro, Marcio B
AU  - Castro MB
FAU - Cunha, Wilson R
AU  - Cunha WR
FAU - Tavares, Denise C
AU  - Tavares DC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080508
PL  - United States
TA  - Toxicol Pathol
JT  - Toxicologic pathology
JID - 7905907
RN  - 0 (Anticarcinogenic Agents)
RN  - 0 (Triterpenes)
RN  - 6SMK8R7TGJ (Oleanolic Acid)
RN  - IX068S9745 (1,2-Dimethylhydrazine)
SB  - IM
MH  - 1,2-Dimethylhydrazine/*toxicity
MH  - Animals
MH  - Anticarcinogenic Agents/administration & dosage/isolation & 
      purification/*therapeutic use
MH  - Colonic Neoplasms/chemically induced/pathology/*prevention & control
MH  - Male
MH  - Melastomataceae/chemistry
MH  - Oleanolic Acid/administration & dosage/isolation & purification/*therapeutic use
MH  - Plant Components, Aerial/chemistry
MH  - Precancerous Conditions/chemically induced/pathology/*prevention & control
MH  - Rats
MH  - Rats, Wistar
MH  - Triterpenes/administration & dosage/isolation & purification/*therapeutic use
MH  - Ursolic Acid
EDAT- 2008/05/10 09:00
MHDA- 2008/10/22 09:00
CRDT- 2008/05/10 09:00
PHST- 2008/05/10 09:00 [pubmed]
PHST- 2008/10/22 09:00 [medline]
PHST- 2008/05/10 09:00 [entrez]
AID - 0192623308317423 [pii]
AID - 10.1177/0192623308317423 [doi]
PST - ppublish
SO  - Toxicol Pathol. 2008 Jun;36(4):576-80. doi: 10.1177/0192623308317423. Epub 2008 
      May 8.