PMID- 18468429
OWN - NLM
STAT- MEDLINE
DCOM- 20080617
LR  - 20170306
VI  - 115
IP  - 3
DP  - 2006 Mar
TI  - [Hyperhomocysteinemia complicated by myocardial infarction and portal vein 
      thrombosis--case report].
PG  - 234-7
AB  - Hyperhomocysteinemia (HHcy) can be associated with deficiency of group B vitamins 
      and folic acid. HHcy might also results from renal insufficiency, diabetes, 
      hypothyreosis or malignant diseases. In same cases HHcy is connected with 
      mutations of genes involved in its metabolism. HHcy causes the increased risk of 
      arterial and vein thrombosis. In this paper we show case report of woman with 
      HHcy, who developed several complications, probably because of HHcy. This patient 
      in the age of 38 and 44 years developed twice myocardial infarction, whereas in 
      the age of 48 she suffered from portal vein thrombosis. According to 
      documentation, the level of cholesterol has never been elevated, however HHcy was 
      observed. During diagnostic process, the primary and secondary causes of HHcy 
      were assessed. Mutations of genes involved in Hcy metabolism were also assessed. 
      We did not find any mutation in protein products of methylenotetrahydrofolate 
      reductase (MTHFR) or cystationine beta-synthase (CBS). The patient was treated 
      with the use of folic acid, vitamin B12 and B6 supplementation, and normalization 
      of Hcy level was received. This case report underline, how important role in the 
      case of HHcy play vitamin supplementation. The early treatment of HHcy might 
      limit thromboembolic complication.
FAU - Dworakowska, Dorota
AU  - Dworakowska D
AD  - Klinika Chorob Wewnetrznych, Endokrynologii i Zaburzen Hemostazy, Akademia 
      Medyczna w Gdansku. ddw@amg.gda.pl
FAU - Kazimierska, Ewa
AU  - Kazimierska E
FAU - Weyer-Hepka, Jolanta
AU  - Weyer-Hepka J
FAU - Dworakowski, Rafal
AU  - Dworakowski R
FAU - Jakobiewicz-Banecka, Joanna
AU  - Jakobiewicz-Banecka J
FAU - Suwala, Wojciech
AU  - Suwala W
FAU - Czestochowska, Eugenia
AU  - Czestochowska E
LA  - pol
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
TT  - Hiperhomocysteinemia powiklana zawalem miesnia sercowego oraz zakrzepica zyly 
      wrotnej--opis przypadku.
PL  - Poland
TA  - Pol Arch Med Wewn
JT  - Polskie Archiwum Medycyny Wewnetrznej
JID - 0401225
RN  - 935E97BOY8 (Folic Acid)
RN  - P6YC3EG204 (Vitamin B 12)
SB  - IM
MH  - Female
MH  - Folic Acid/therapeutic use
MH  - Humans
MH  - Hyperhomocysteinemia/blood/*complications/drug therapy
MH  - Middle Aged
MH  - Myocardial Infarction/*etiology
MH  - *Portal Vein
MH  - Thrombosis/*etiology
MH  - Treatment Outcome
MH  - Vitamin B 12/therapeutic use
EDAT- 2008/05/13 09:00
MHDA- 2008/06/18 09:00
CRDT- 2008/05/13 09:00
PHST- 2008/05/13 09:00 [pubmed]
PHST- 2008/06/18 09:00 [medline]
PHST- 2008/05/13 09:00 [entrez]
PST - ppublish
SO  - Pol Arch Med Wewn. 2006 Mar;115(3):234-7.