PMID- 18468792
OWN - NLM
STAT- MEDLINE
DCOM- 20080919
LR  - 20131121
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 438
IP  - 2
DP  - 2008 Jun 20
TI  - Oxytocin facilitates the induction of long-term potentiation in the accessory 
      olfactory bulb.
PG  - 133-7
LID - 10.1016/j.neulet.2007.12.070 [doi]
AB  - When female mice are mated, they form a memory to the pheromonal signal of their 
      male partner. Several lines of evidence indicate that the neural changes 
      underlying this memory occur in the accessory olfactory bulb (AOB) at the first 
      stage of the vomeronasal system. The formation of this memory depends on the 
      mating-induced release of noradrenaline in the AOB. In addition to noradrenaline, 
      the neuropeptide oxytocin (OT) is also released within the central nervous system 
      during mating. Because OT has been implicated in social memory and its receptors 
      are expressed in the AOB, we hypothesized that OT might promote the strength of 
      synaptic transmission from mitral to granule cells in the AOB. To test this 
      hypothesis, we analyzed the lateral olfactory tract-evoked field potential that 
      represents the granule cell response to mitral cell activation and its plasticity 
      in parasagittal slices of the AOB. Of the 10-, 20-, 50-, and 100-Hz stimulations 
      tested, the 100-Hz stimulation was optimal for inducing long-term potentiation 
      (LTP). OT paired with 100-Hz stimulation that only produced short-term 
      potentiation enhanced LTP induction in a dose-dependent manner. OT-paired LTP was 
      blocked by both the selective OT antagonist 
      desGly-NH(2),d(CH(2))(5)[Tyr(Me)(2),Thr(4)]-ornithine vasotocin and the 
      N-methyl-d-aspartate (NMDA) receptor antagonist dl-2-amino-5-phosphonovaleric 
      acid. These results indicate that OT can function as a gate to modulate the 
      establishment of NMDA receptor-dependent LTP at the mitral-to-granule cell 
      synapse in the AOB.
FAU - Fang, Long-Yun
AU  - Fang LY
AD  - Department of Physiology, Kochi Medical School, Nankoku, Kochi 783-8505, Japan.
FAU - Quan, Rong-Dan
AU  - Quan RD
FAU - Kaba, Hideto
AU  - Kaba H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080416
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 0 (Sex Attractants)
RN  - 50-56-6 (Oxytocin)
RN  - W6S6URY8OF (Vasotocin)
SB  - IM
MH  - Animals
MH  - Electric Stimulation
MH  - Excitatory Amino Acid Antagonists/pharmacology
MH  - Female
MH  - Long-Term Potentiation/drug effects/*physiology
MH  - Male
MH  - Memory/drug effects/physiology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Neurons/drug effects/*metabolism
MH  - Olfactory Bulb/cytology/drug effects/*metabolism
MH  - Olfactory Pathways/drug effects/metabolism
MH  - Organ Culture Techniques
MH  - Oxytocin/analogs & derivatives/*metabolism/pharmacology
MH  - Receptors, N-Methyl-D-Aspartate/drug effects/*metabolism
MH  - Sex Attractants/physiology
MH  - Sexual Behavior, Animal/physiology
MH  - Signal Transduction/drug effects/physiology
MH  - Synapses/drug effects/metabolism
MH  - Synaptic Transmission/drug effects/*physiology
MH  - Vasotocin/analogs & derivatives/pharmacology
MH  - Vomeronasal Organ/physiology
EDAT- 2008/05/13 09:00
MHDA- 2008/09/20 09:00
CRDT- 2008/05/13 09:00
PHST- 2007/10/23 00:00 [received]
PHST- 2007/12/15 00:00 [revised]
PHST- 2007/12/18 00:00 [accepted]
PHST- 2008/05/13 09:00 [pubmed]
PHST- 2008/09/20 09:00 [medline]
PHST- 2008/05/13 09:00 [entrez]
AID - S0304-3940(08)00469-2 [pii]
AID - 10.1016/j.neulet.2007.12.070 [doi]
PST - ppublish
SO  - Neurosci Lett. 2008 Jun 20;438(2):133-7. doi: 10.1016/j.neulet.2007.12.070. Epub 
      2008 Apr 16.