PMID- 1846951
OWN - NLM
STAT- MEDLINE
DCOM- 19910311
LR  - 20171116
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 349
IP  - 6309
DP  - 1991 Feb 7
TI  - Induction of CD4 and susceptibility to HIV-1 infection in human CD8+ T 
      lymphocytes by human herpesvirus 6.
PG  - 533-5
AB  - During intrathymic T-cell ontogenesis, functionally competent CD3+CD4+CD8- and 
      CD3+CD4-CD8+ T lymphocytes develop from immature CD4-CD8- thymocytes after 
      transiently acquiring a double-positive CD4+CD8+ phenotype. The partition between 
      CD4+CD8- and CD4-CD8+ T cells is generally considered to be irreversible, 
      although a small percentage of circulating CD3+ T lymphocytes coexpressing CD4 
      and CD8 molecules has been identified. It has been suggested that in CD8+ T cells 
      the CD4 genes may be methylated and thus highly repressed, whereas in CD4+ T 
      cells the CD8 genes are unmethylated and their transcription can be induced by 
      physiological stimuli such as interleukin-4. Here, we demonstrate that infection 
      with human herpesvirus 6 (HHV-6), a virus proposed as a potential cofactor in 
      AIDS, dramatically upregulates the expression of CD4--the receptor for human 
      immunodeficiency virus type-1 (HIV-1)--in a human neoplastic T-cell line. More 
      importantly, HHV-6 induces de novo expression of CD4 messenger RNA and protein in 
      normal mature CD8+ T lymphocytes, rendering them susceptible to infection with 
      HIV-1. These findings demonstrate that human CD3+CD4-CD8+ T lymphocytes can 
      reacquire CD4 in the post-thymic life and elucidate a novel mechanism--receptor 
      regulation--through which HHV-6 may positively interact with HIV-1 in coinfected 
      patients.
FAU - Lusso, P
AU  - Lusso P
AD  - Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 
      20892.
FAU - De Maria, A
AU  - De Maria A
FAU - Malnati, M
AU  - Malnati M
FAU - Lori, F
AU  - Lori F
FAU - DeRocco, S E
AU  - DeRocco SE
FAU - Baseler, M
AU  - Baseler M
FAU - Gallo, R C
AU  - Gallo RC
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Differentiation, T-Lymphocyte)
RN  - 0 (CD3 Complex)
RN  - 0 (CD4 Antigens)
RN  - 0 (CD8 Antigens)
RN  - 0 (Oligonucleotides)
RN  - 0 (Receptors, Antigen, T-Cell)
SB  - IM
MH  - Antibodies, Monoclonal
MH  - Antigens, CD/analysis
MH  - Antigens, Differentiation, T-Lymphocyte/metabolism
MH  - Base Sequence
MH  - CD3 Complex
MH  - CD4 Antigens/*metabolism
MH  - CD8 Antigens
MH  - Cell Line
MH  - HIV Infections/*microbiology
MH  - Herpesviridae Infections/*metabolism
MH  - Herpesvirus 6, Human/*metabolism
MH  - Humans
MH  - In Vitro Techniques
MH  - Molecular Sequence Data
MH  - Oligonucleotides/chemistry
MH  - Polymerase Chain Reaction
MH  - Receptors, Antigen, T-Cell/metabolism
MH  - T-Lymphocyte Subsets/immunology/*microbiology
EDAT- 1991/02/07 00:00
MHDA- 1991/02/07 00:01
CRDT- 1991/02/07 00:00
PHST- 1991/02/07 00:00 [pubmed]
PHST- 1991/02/07 00:01 [medline]
PHST- 1991/02/07 00:00 [entrez]
AID - 10.1038/349533a0 [doi]
PST - ppublish
SO  - Nature. 1991 Feb 7;349(6309):533-5. doi: 10.1038/349533a0.