PMID- 18469698
OWN - NLM
STAT- MEDLINE
DCOM- 20080924
LR  - 20090709
IS  - 1528-1159 (Electronic)
IS  - 0362-2436 (Linking)
VI  - 33
IP  - 11
DP  - 2008 May 15
TI  - Genetic factors are associated with modic changes in endplates of lumbar 
      vertebral bodies.
PG  - 1236-41
LID - 10.1097/BRS.0b013e318170fd0e [doi]
AB  - STUDY DESIGN: A cross-sectional genotype-phenotype evaluation. OBJECTIVE: To 
      evaluate the genetic background to Modic changes in an occupational cohort. 
      SUMMARY OF BACKGROUND DATA: Modic changes are vertebral endplate changes visible 
      in magnetic resonance imaging. Twin studies suggest that intervertebral disc 
      degeneration may be primarily explained by genetic factors, but no data exist on 
      genetic factors of Modic changes. METHODS: Thirteen variations in 8 genes 
      (COL9A2, COL9A3, COL11A2, IL1A, IL1B, IL6, MMP3, and VDR) were genotyped in an 
      occupational cohort of 159 male train engineers and 69 male paper mill workers. 
      All the subjects were scanned by magnetic resonance imaging and evaluated for 
      Modic changes. RESULTS: Out of the 228 subjects, 128 (56%) were found to have 
      Modic changes at one or more disc levels, exclusively of type I in 15%, of type 
      II in 32%, and of both type I and type II in 10%. None of the single nucleotide 
      polymorphisms was significantly associated with Modic changes when analyzed 
      independently, but when gene-gene interactions were evaluated, interleukin-1A 
      (IL1A) and matrix metalloproteinase-3 (MMP3) polymorphisms together were 
      associated with type II Modic changes (OR = 3.2, 95% CI = 1.2-8.5; P = 0.038), as 
      was the IL1 gene cluster together with the MMP3 polymorphism (OR = 8.14, 95% CI = 
      1.72-38.44; P = 0.008). DISCUSSION: This is the first study evaluating the role 
      of genetic factors in relation to Modic changes. Genetic variations in the IL1 
      cluster and the MMP3 gene together were found to be significantly associated with 
      type II Modic changes.
FAU - Karppinen, Jaro
AU  - Karppinen J
AD  - Musculoskeletal Centre, Finnish Institute of Occupational Health, Oulu, Finland. 
      jaro.karppinen@ttl.fi
FAU - Daavittila, Iita
AU  - Daavittila I
FAU - Solovieva, Svetlana
AU  - Solovieva S
FAU - Kuisma, Mari
AU  - Kuisma M
FAU - Taimela, Simo
AU  - Taimela S
FAU - Natri, Antero
AU  - Natri A
FAU - Haapea, Marianne
AU  - Haapea M
FAU - Korpelainen, Raija
AU  - Korpelainen R
FAU - Niinimaki, Jaakko
AU  - Niinimaki J
FAU - Tervonen, Osmo
AU  - Tervonen O
FAU - Ala-Kokko, Leena
AU  - Ala-Kokko L
FAU - Mannikko, Minna
AU  - Mannikko M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Spine (Phila Pa 1976)
JT  - Spine
JID - 7610646
SB  - IM
MH  - Adult
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - Genotype
MH  - Humans
MH  - Lumbar Vertebrae/*abnormalities/*physiology
MH  - Male
MH  - Middle Aged
MH  - *Phenotype
MH  - Polymorphism, Genetic/genetics
MH  - Spinal Diseases/genetics/pathology
EDAT- 2008/05/13 09:00
MHDA- 2008/09/25 09:00
CRDT- 2008/05/13 09:00
PHST- 2008/05/13 09:00 [pubmed]
PHST- 2008/09/25 09:00 [medline]
PHST- 2008/05/13 09:00 [entrez]
AID - 00007632-200805150-00013 [pii]
AID - 10.1097/BRS.0b013e318170fd0e [doi]
PST - ppublish
SO  - Spine (Phila Pa 1976). 2008 May 15;33(11):1236-41. doi: 
      10.1097/BRS.0b013e318170fd0e.