PMID- 18469866
OWN - NLM
STAT- MEDLINE
DCOM- 20080916
LR  - 20161124
IS  - 1476-5594 (Electronic)
IS  - 0950-9232 (Linking)
VI  - 27
IP  - 34
DP  - 2008 Aug 7
TI  - Disruption of the hexokinase-VDAC complex for tumor therapy.
PG  - 4633-5
LID - 10.1038/onc.2008.114 [doi]
AB  - Unlike mitochondria from most normal tissues, cancer cell mitochondria 
      demonstrate an association between the glycolytic enzyme hexokinase (HK) and the 
      voltage-dependent anion channel (VDAC). This provides a therapeutic opportunity, 
      as the association appears to protect tumor cells from mitochondrial outer 
      membrane permeabilization (MOMP), an event that marks the point of no return in 
      multiple pathways leading to cell death. In this issue of Oncogene, the plant 
      hormone methyl jasmonate (MJ) is shown to disrupt the interaction between human 
      HK and VDAC, causing the inhibition of glycolysis and the induction of MOMP. MJ 
      has already been shown to have selective anticancer activity in preclinical 
      studies, and this finding may stimulate the development of a novel class of small 
      anticancer compounds that inhibit the HK-VDAC interaction.
FAU - Galluzzi, L
AU  - Galluzzi L
AD  - INSERM, U848, 39 rue C. Desmoulins, Villejuif, France.
FAU - Kepp, O
AU  - Kepp O
FAU - Tajeddine, N
AU  - Tajeddine N
FAU - Kroemer, G
AU  - Kroemer G
LA  - eng
PT  - Comment
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080512
PL  - England
TA  - Oncogene
JT  - Oncogene
JID - 8711562
RN  - 0 (Acetates)
RN  - 0 (Cyclopentanes)
RN  - 0 (Multiprotein Complexes)
RN  - 0 (Oxylipins)
RN  - 0 (Plant Extracts)
RN  - 0 (Voltage-Dependent Anion Channels)
RN  - 900N171A0F (methyl jasmonate)
RN  - EC 2.7.1.1 (Hexokinase)
SB  - IM
CON - Oncogene. 2008 Aug 7;27(34):4636-43. PMID: 18408762
MH  - Acetates/therapeutic use
MH  - Cyclopentanes/therapeutic use
MH  - Hexokinase/*metabolism
MH  - Humans
MH  - Models, Biological
MH  - Multiprotein Complexes/metabolism
MH  - Neoplasms/*drug therapy
MH  - Oxylipins/therapeutic use
MH  - Phytotherapy
MH  - Plant Extracts/therapeutic use
MH  - Protein Binding/drug effects
MH  - Voltage-Dependent Anion Channels/*metabolism
EDAT- 2008/05/13 09:00
MHDA- 2008/09/17 09:00
CRDT- 2008/05/13 09:00
PHST- 2008/05/13 09:00 [pubmed]
PHST- 2008/09/17 09:00 [medline]
PHST- 2008/05/13 09:00 [entrez]
AID - onc2008114 [pii]
AID - 10.1038/onc.2008.114 [doi]
PST - ppublish
SO  - Oncogene. 2008 Aug 7;27(34):4633-5. doi: 10.1038/onc.2008.114. Epub 2008 May 12.