PMID- 18470720
OWN - NLM
STAT- MEDLINE
DCOM- 20090430
LR  - 20181201
IS  - 1432-1238 (Electronic)
IS  - 0342-4642 (Linking)
VI  - 26 Suppl 2
DP  - 2000 Mar
TI  - Procalcitonin for discrimination between activity of systemic autoimmune disease 
      and systemic bacterial infection.
PG  - S199-201
LID - 10.1007/BF02900738 [doi]
AB  - OBJECTIVE: To investigate whether serum procalcitonin (PCT) levels could be 
      useful to differentiate between systemic infection and the activity of the 
      underlying disease in autoimmune disease. METHODS: In 18 patients with systemic 
      lupus erythematodes (SLE) and 35 patients with systemic antineutrophil 
      cytoplasmic antibody-associated vasculitis (AAV) clinical disease activity was 
      assessed by score systems. Infection was defined by clinical and microbiological 
      means. PCT was determined in parallel with concentrations of neopterin, 
      interleukin-6 (IL-6), and C-reactive protein (CRP) in 397 serum samples. RESULTS: 
      Only in 3 of the 324 samples taken from patients with autoimmune disease but 
      without concomitant infection, serum PCT levels were above the normal range (>0.5 
      ng/ml), whereas neopterin, CRP and IL-6 were elevated in patients with active 
      underlying disease. All systemic infections (N=16 in AAV-patients) were 
      associated with markedly elevated PCT-levels (mean+/-SD:1.93+/-1.19 ng/ml). 
      CONCLUSION: PCT may serve as a useful marker for the detection of systemic 
      bacterial infection in patients with autoimmune disease.
FAU - Brunkhorst, R
AU  - Brunkhorst R
AD  - Medizinische Hochschule Hannover, Abt. Nephrologie, Carl-Neubert-Str.1, D-30623 
      Hannover, Germany. brunkhorst@tx.amb-hannover.de
FAU - Eberhardt, O K
AU  - Eberhardt OK
FAU - Haubitz, M
AU  - Haubitz M
FAU - Brunkhorst, F M
AU  - Brunkhorst FM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Intensive Care Med
JT  - Intensive care medicine
JID - 7704851
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
RN  - 0 (Biomarkers)
RN  - 0 (CALCA protein, human)
RN  - 0 (Protein Precursors)
RN  - 9007-12-9 (Calcitonin)
RN  - JHB2QIZ69Z (Calcitonin Gene-Related Peptide)
SB  - IM
MH  - Adult
MH  - Antibodies, Antineutrophil Cytoplasmic/*blood
MH  - Bacterial Infections/blood/*diagnosis
MH  - Biomarkers/blood
MH  - Calcitonin/*blood
MH  - Calcitonin Gene-Related Peptide
MH  - Diagnosis, Differential
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Lupus Erythematosus, Systemic/blood/*diagnosis
MH  - Male
MH  - Middle Aged
MH  - Protein Precursors/*blood
MH  - Sensitivity and Specificity
MH  - Vasculitis/blood/*diagnosis
EDAT- 2008/05/13 09:00
MHDA- 2009/05/01 09:00
CRDT- 2008/05/13 09:00
PHST- 2008/05/13 09:00 [pubmed]
PHST- 2009/05/01 09:00 [medline]
PHST- 2008/05/13 09:00 [entrez]
AID - 10.1007/BF02900738 [doi]
PST - ppublish
SO  - Intensive Care Med. 2000 Mar;26 Suppl 2:S199-201. doi: 10.1007/BF02900738.