PMID- 18471144
OWN - NLM
STAT- MEDLINE
DCOM- 20080724
LR  - 20191210
IS  - 1365-2885 (Electronic)
IS  - 0140-7783 (Linking)
VI  - 31
IP  - 3
DP  - 2008 Jun
TI  - Evaluation of the interaction between ivermectin and albendazole following their 
      combined use in lambs.
PG  - 230-9
LID - 10.1111/j.1365-2885.2008.00953.x [doi]
AB  - Mixtures of drugs from different chemical families have been proposed as a valid 
      strategy to delay the development of anthelmintic resistance. The current work 
      summarizes the outcome of the evaluation of the plasma disposition kinetics of 
      albendazole (ABZ) and ivermectin (IVM) administered either alone or 
      co-administered to lambs infected with gastrointestinal (GI) nematodes resistant 
      to both anthelmintic molecules. Thirty six (36) Corriedale lambs naturally 
      infected with multiple resistant GI nematodes were allocated into six treatment 
      groups: (a) ABZ intravenous (ABZ(IV)); (b) IVM(IV); (c) ABZ(IV) + IVM(IV); (d) 
      ABZ intraruminal (IR); (e) IVM subcutaneous (SC) and (f) ABZ(IR) + IVM(SC). 
      Plasma samples were collected over 15 days post-treatment and analysed by HPLC. 
      The estimated pharmacokinetic (PK) parameters were statistically compared using 
      parametric and non-parametric statistical tests. The presence of IVM did not 
      affect the plasma disposition kinetics of ABZ and its metabolites after the i.v. 
      administration. However, the ABZ sulphoxide (ABZSO) area under the concentration 
      vs. time curve (AUC) was significantly lower (P < 0.01) after the intraruminal 
      (i.r.) administration of ABZ alone compared to that obtained for the combined 
      treatment with IVM [subcutaneous (s.c.) injection]. The IVM plasma AUC obtained 
      after its i.v. co-administration with ABZ was 88% higher (P < 0.05) compared to 
      the treatment with IVM alone. Any marked difference on IVM PK parameters was 
      observed between the treatments ABZ + IVM and IVM alone injected subcutaneously. 
      The data obtained here indicate that the co-administration of ABZ and IVM does 
      not induce an adverse kinetic interaction. This type of pharmacology-based 
      evaluation of drug interactions is becoming highly relevant as drug combinations 
      are now widely used as an alternative to control resistant helminth parasites in 
      livestock.
FAU - Alvarez, L
AU  - Alvarez L
AD  - Laboratorio de Farmacologia, Facultad de Ciencias Veterinarias, Universidad 
      Nacional del Centro de la Provincia de Buenos Aires (UNCPBA), Campus 
      Universitario, Tandil, Argentina.
FAU - Lifschitz, A
AU  - Lifschitz A
FAU - Entrocasso, C
AU  - Entrocasso C
FAU - Manazza, J
AU  - Manazza J
FAU - Mottier, L
AU  - Mottier L
FAU - Borda, B
AU  - Borda B
FAU - Virkel, G
AU  - Virkel G
FAU - Lanusse, C
AU  - Lanusse C
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Vet Pharmacol Ther
JT  - Journal of veterinary pharmacology and therapeutics
JID - 7910920
RN  - 0 (Anthelmintics)
RN  - 70288-86-7 (Ivermectin)
RN  - F4216019LN (Albendazole)
SB  - IM
MH  - Albendazole/metabolism/pharmacokinetics/*therapeutic use
MH  - Animals
MH  - Anthelmintics/blood/pharmacokinetics/*therapeutic use
MH  - Area Under Curve
MH  - Biological Availability
MH  - Chromatography, High Pressure Liquid
MH  - Dose-Response Relationship, Drug
MH  - Drug Interactions
MH  - Drug Therapy, Combination
MH  - Female
MH  - Half-Life
MH  - Ivermectin/blood/pharmacokinetics/*therapeutic use
MH  - Metabolic Clearance Rate
MH  - Nematode Infections/drug therapy/*veterinary
MH  - Sheep
MH  - Sheep Diseases/*drug therapy/metabolism
MH  - Tissue Distribution
EDAT- 2008/05/13 09:00
MHDA- 2008/07/25 09:00
CRDT- 2008/05/13 09:00
PHST- 2008/05/13 09:00 [pubmed]
PHST- 2008/07/25 09:00 [medline]
PHST- 2008/05/13 09:00 [entrez]
AID - JVP953 [pii]
AID - 10.1111/j.1365-2885.2008.00953.x [doi]
PST - ppublish
SO  - J Vet Pharmacol Ther. 2008 Jun;31(3):230-9. doi: 
      10.1111/j.1365-2885.2008.00953.x.