PMID- 18471780
OWN - NLM
STAT- MEDLINE
DCOM- 20080811
LR  - 20220410
IS  - 1521-690X (Print)
IS  - 1521-690X (Linking)
VI  - 22
IP  - 2
DP  - 2008 Apr
TI  - Androgen biosynthetic pathways in the human prostate.
PG  - 207-21
LID - 10.1016/j.beem.2008.01.008 [doi]
AB  - It is well recognized that there are two androgens, namely testosterone (T) and 
      dihydrotestosterone (DHT); T plays an important role in the testis and muscle, 
      and DHT is crucial for the development, function and pathology of the prostate. 
      It is generally thought that DHT is produced from the 5alpha-reduction of 
      circulating T before being inactivated by 3alpha-hydroxysteroid dehydrogenase 
      (3alpha-HSD) that converts DHT into 5alpha-androstane-3alpha,17beta-diol 
      (3alpha-diol). However, the presence of various steroidogenic enzymes in the 
      prostate as well as the availability at high levels of various steroid precursors 
      such as dehydroepiandrosterone sulphate (DHEAS), dehydroepiandrosterone (DHEA) 
      and 4-androstenedione (4-dione) strongly suggest the existence of additional 
      pathways involved in the biosynthesis and metabolism of DHT. Because 
      steroidogenesis could be different in different species, data from the literature 
      obtained from various human, dog, rat and mouse prostate tissues, as well as 
      primary cells and prostatic cancer cell lines, provide a somewhat confusing 
      picture. In the present chapter, we review the data in order to provide a clearer 
      picture of the pathways involved in DHT biosynthesis and metabolism in the human 
      prostate.
FAU - Luu-The, Van
AU  - Luu-The V
AD  - Laboratory of Molecular Endocrinology and Oncology, Laval University Hospital 
      Research Center, Laval University, Quebec, Canada. van.luu-the@crchul.ulaval.ca
FAU - Belanger, Alain
AU  - Belanger A
FAU - Labrie, Fernand
AU  - Labrie F
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Best Pract Res Clin Endocrinol Metab
JT  - Best practice & research. Clinical endocrinology & metabolism
JID - 101120682
RN  - 0 (Androgens)
RN  - 08J2K08A3Y (Dihydrotestosterone)
RN  - 3XMK78S47O (Testosterone)
RN  - EC 1.- (Oxidoreductases)
RN  - EC 1.1.- (Hydroxysteroid Dehydrogenases)
SB  - IM
MH  - Androgens/*biosynthesis
MH  - Animals
MH  - Biosynthetic Pathways/*physiology
MH  - Dihydrotestosterone/metabolism
MH  - Humans
MH  - Hydroxysteroid Dehydrogenases/metabolism/physiology
MH  - Male
MH  - Models, Biological
MH  - Oxidoreductases/metabolism/physiology
MH  - Prostate/enzymology/*metabolism
MH  - Testosterone/metabolism
RF  - 100
EDAT- 2008/05/13 09:00
MHDA- 2008/08/12 09:00
CRDT- 2008/05/13 09:00
PHST- 2008/05/13 09:00 [pubmed]
PHST- 2008/08/12 09:00 [medline]
PHST- 2008/05/13 09:00 [entrez]
AID - S1521-690X(08)00009-2 [pii]
AID - 10.1016/j.beem.2008.01.008 [doi]
PST - ppublish
SO  - Best Pract Res Clin Endocrinol Metab. 2008 Apr;22(2):207-21. doi: 
      10.1016/j.beem.2008.01.008.