PMID- 18471802
OWN - NLM
STAT- MEDLINE
DCOM- 20081103
LR  - 20240318
IS  - 1873-2402 (Electronic)
IS  - 0006-3223 (Print)
IS  - 0006-3223 (Linking)
VI  - 64
IP  - 4
DP  - 2008 Aug 15
TI  - A postpartum model in rat: behavioral and gene expression changes induced by 
      ovarian steroid deprivation.
PG  - 311-9
LID - 10.1016/j.biopsych.2008.03.029 [doi]
AB  - BACKGROUND: Postpartum depression (PPD) affects approximately 10% to 20% of women 
      during the first 4 weeks of the postpartum period and is characterized by labile 
      mood with prominent anxiety and irritability, insomnia, and depressive mood. 
      During the postpartum period, elevated ovarian hormones abruptly decrease to the 
      early follicular phase levels that are postulated to play a major role in 
      triggering PPD. However, the underlying neurobiological mechanisms that 
      contribute to PPD have not been determined. METHODS: In the present study, we 
      examined the effect of ovarian steroids, administered at levels that occur during 
      human pregnancy followed by rapid withdrawal to simulate postpartum conditions, 
      on behavior and gene expression in the rat. RESULTS: The results of behavioral 
      testing reveal that the hormone-simulated postpartum treatment results in the 
      development of a phenotype relevant to PPD, including vulnerability for 
      helplessness, increased anxiety, and aggression. Real-time quantitative 
      polymerase chain reaction (PCR) demonstrated transient regulation of several 
      genes, including Ca(2+)/calmodulin-dependent protein kinase II (CAMKII), 
      serotonin transporter (SERT), myocyte enhancer factor 2A (MEF2A), brain-derived 
      neurotrophic factor (BDNF), gamma-aminobutyric acid type A receptor alpha 4 
      (GABAARA4), mothers against decapentaplegic homolog 4 (SMAD4), and aquaporin 4 
      (AQP4) that could underlie these behavioral effects. CONCLUSIONS: These studies 
      provide an improved understanding of the effects of withdrawal from high doses of 
      ovarian hormones on behavior and gene expression changes in the brain that could 
      contribute to the pathophysiology of PPD.
FAU - Suda, Shiro
AU  - Suda S
AD  - Division of Molecular Psychiatry, Abraham Ribicoff Research Facilities, 
      Connecticut Mental Health Center, Yale University School of Medicine, New Haven, 
      Connecticut 06508, USA.
FAU - Segi-Nishida, Eri
AU  - Segi-Nishida E
FAU - Newton, Samuel S
AU  - Newton SS
FAU - Duman, Ronald S
AU  - Duman RS
LA  - eng
GR  - P01 MH025642/MH/NIMH NIH HHS/United States
GR  - 2 PO1 MH25642/MH/NIMH NIH HHS/United States
GR  - MH45481/MH/NIMH NIH HHS/United States
GR  - R37 MH045481/MH/NIMH NIH HHS/United States
GR  - R01 MH045481/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20080508
PL  - United States
TA  - Biol Psychiatry
JT  - Biological psychiatry
JID - 0213264
RN  - 0 (Aquaporin 4)
RN  - 0 (MEF2 Transcription Factors)
RN  - 0 (Myogenic Regulatory Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Receptors, GABA-A)
RN  - 0 (Steroids)
RN  - 4TI98Z838E (Estradiol)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinase Type 2)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Aquaporin 4/genetics/metabolism
MH  - Behavior, Animal/drug effects/*physiology
MH  - Calcium-Calmodulin-Dependent Protein Kinase Type 2/genetics/metabolism
MH  - *Depression, Postpartum/etiology/genetics/psychology
MH  - Disease Models, Animal
MH  - Estradiol/pharmacology
MH  - Exploratory Behavior/drug effects
MH  - Female
MH  - Gene Expression Regulation/drug effects/*physiology
MH  - Helplessness, Learned
MH  - MEF2 Transcription Factors
MH  - Maze Learning/drug effects/physiology
MH  - Myogenic Regulatory Factors/genetics/metabolism
MH  - Nerve Tissue Proteins/genetics/metabolism
MH  - Ovariectomy/methods
MH  - Postpartum Period/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, GABA-A/genetics/metabolism
MH  - Steroids/*metabolism
MH  - Swimming
PMC - PMC3714803
MID - NIHMS477747
COIS- The authors reported no biomedical financial interests or potential conflicts of 
      interest.
EDAT- 2008/05/13 09:00
MHDA- 2008/11/04 09:00
PMCR- 2013/07/18
CRDT- 2008/05/13 09:00
PHST- 2007/08/27 00:00 [received]
PHST- 2008/03/26 00:00 [revised]
PHST- 2008/03/31 00:00 [accepted]
PHST- 2008/05/13 09:00 [pubmed]
PHST- 2008/11/04 09:00 [medline]
PHST- 2008/05/13 09:00 [entrez]
PHST- 2013/07/18 00:00 [pmc-release]
AID - S0006-3223(08)00395-8 [pii]
AID - 10.1016/j.biopsych.2008.03.029 [doi]
PST - ppublish
SO  - Biol Psychiatry. 2008 Aug 15;64(4):311-9. doi: 10.1016/j.biopsych.2008.03.029. 
      Epub 2008 May 8.