PMID- 18471833
OWN - NLM
STAT- MEDLINE
DCOM- 20081001
LR  - 20080616
IS  - 0025-326X (Print)
IS  - 0025-326X (Linking)
VI  - 57
IP  - 6-12
DP  - 2008
TI  - Use of exposure time and life expectancy in models for toxicity to aquatic 
      organisms.
PG  - 245-9
LID - 10.1016/j.marpolbul.2008.03.034 [doi]
AB  - The exposure time is a variable which is usually not incorporated into models for 
      toxicity. However, with persistent organic pollutants (POPs) exhibiting a 
      nonspecific mode of action and lipophilic properties this variable can be modeled 
      by the usage of the internal concentrations as a measure of the toxicity with 
      fish. The bioconcentration process with fish is a relatively well understood and 
      predictable process which allows the calculation of the internal lethal 
      concentration. When the exposure time is relatively short the critical internal 
      lethal concentrations are relatively constant for the group of POPs whereaas the 
      LC50 measured in the ambient water is quite variable. When the exposure time is 
      relatively long, results on the measurement of the critical internal 
      concentration with fish over different exposure times has demonstrated that the 
      internal lethal concentration falls with increasing exposure times in a 
      consistent and predictable manner. This reduction in life expectancy can be 
      described in a model which can be used to estimate the critical internal 
      concentration for any exposure time. It also provides information useful in 
      assessing the risk to fish and potentially other species due to the occurrence of 
      residues of POPs in natural aquatic systems. It is suggested that these 
      relationships can be extended to other groups of organisms and chemicals.
FAU - Connell, Des
AU  - Connell D
AD  - Griffith School of Environment, Griffith University, Nathan Campus, Brisbane, 
      Queensland 4111, Australia. D.Connell@griffith.edu.au
FAU - Yu, Jimmy
AU  - Yu J
LA  - eng
PT  - Journal Article
DEP - 20080508
PL  - England
TA  - Mar Pollut Bull
JT  - Marine pollution bulletin
JID - 0260231
RN  - 0 (Water Pollutants, Chemical)
SB  - IM
MH  - Animals
MH  - Ecotoxicology/*methods
MH  - *Environmental Exposure
MH  - Fishes
MH  - Lethal Dose 50
MH  - Life Expectancy
MH  - Longevity/*drug effects
MH  - *Models, Biological
MH  - Risk Assessment/methods
MH  - Time Factors
MH  - Water Pollutants, Chemical/metabolism/*toxicity
EDAT- 2008/05/13 09:00
MHDA- 2008/10/02 09:00
CRDT- 2008/05/13 09:00
PHST- 2007/07/27 00:00 [received]
PHST- 2008/03/14 00:00 [revised]
PHST- 2008/03/21 00:00 [accepted]
PHST- 2008/05/13 09:00 [pubmed]
PHST- 2008/10/02 09:00 [medline]
PHST- 2008/05/13 09:00 [entrez]
AID - S0025-326X(08)00189-6 [pii]
AID - 10.1016/j.marpolbul.2008.03.034 [doi]
PST - ppublish
SO  - Mar Pollut Bull. 2008;57(6-12):245-9. doi: 10.1016/j.marpolbul.2008.03.034. Epub 
      2008 May 8.