PMID- 18472202
OWN - NLM
STAT- MEDLINE
DCOM- 20081105
LR  - 20131121
IS  - 0278-5846 (Print)
IS  - 0278-5846 (Linking)
VI  - 32
IP  - 5
DP  - 2008 Jul 1
TI  - The association of genotypic combination of the DRD3 and BDNF polymorphisms on 
      the adhesio interthalamica and medial temporal lobe structures.
PG  - 1236-42
LID - 10.1016/j.pnpbp.2008.03.014 [doi]
AB  - Abnormal neurodevelopment in midline structures such as the adhesio 
      interthalamica (AI), as well as in the medial temporal lobe structures has been 
      implicated in schizophrenia, while its genetic mechanism is unknown. This 
      magnetic resonance imaging study investigated the effect of the genotypic 
      combination of the dopamine D3 receptor (DRD3) Ser9Gly and brain-derived 
      neurotrophic factor (BDNF) Val66Met polymorphisms on the AI length and volumetric 
      measures of the medial temporal lobe structures (amygdala, hippocampus, and 
      parahippocampal gyrus) in 33 schizophrenia patients and 29 healthy controls. The 
      subjects with a combination of the Ser/Ser genotype of DRD3 and Met-containing 
      genotypes of BDNF (high-risk combination) had a shorter AI than those without it 
      in the healthy controls, but not in the schizophrenia patients. The subjects 
      carrying the high-risk combination had a smaller posterior hippocampus than those 
      without it for both diagnostic groups. These genotypic combination effects on 
      brain morphology were not explained by the independent effect of each 
      polymorphism. These findings suggest the effect of gene-gene interaction between 
      the DRD3 and BDNF variations on brain morphology in midline and medial temporal 
      lobe structures, but do not support its specific role in the pathogenesis of 
      schizophrenia.
FAU - Takahashi, Tsutomu
AU  - Takahashi T
AD  - Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 
      930-0194, Japan.
FAU - Suzuki, Michio
AU  - Suzuki M
FAU - Tsunoda, Masahiko
AU  - Tsunoda M
FAU - Kawamura, Yukiko
AU  - Kawamura Y
FAU - Takahashi, Nagahide
AU  - Takahashi N
FAU - Maeno, Nobuhisa
AU  - Maeno N
FAU - Kawasaki, Yasuhiro
AU  - Kawasaki Y
FAU - Zhou, Shi-Yu
AU  - Zhou SY
FAU - Hagino, Hirofumi
AU  - Hagino H
FAU - Niu, Lisha
AU  - Niu L
FAU - Tsuneki, Hiroshi
AU  - Tsuneki H
FAU - Kobayashi, Soushi
AU  - Kobayashi S
FAU - Sasaoka, Toshiyasu
AU  - Sasaoka T
FAU - Seto, Hikaru
AU  - Seto H
FAU - Kurachi, Masayoshi
AU  - Kurachi M
FAU - Ozaki, Norio
AU  - Ozaki N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080325
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Receptors, Dopamine D3)
RN  - 452VLY9402 (Serine)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
RN  - TE7660XO1C (Glycine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Dominance, Cerebral
MH  - Female
MH  - Genetic Predisposition to Disease/genetics
MH  - Genotype
MH  - Glycine/genetics
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Methionine/genetics
MH  - *Polymorphism, Genetic
MH  - Receptors, Dopamine D3/*genetics
MH  - Schizophrenia/*genetics/*pathology
MH  - Serine/genetics
MH  - Temporal Lobe/*abnormalities/pathology
MH  - Thalamus/*abnormalities/pathology
MH  - Valine/genetics
EDAT- 2008/05/13 09:00
MHDA- 2008/11/06 09:00
CRDT- 2008/05/13 09:00
PHST- 2008/01/31 00:00 [received]
PHST- 2008/03/10 00:00 [revised]
PHST- 2008/03/18 00:00 [accepted]
PHST- 2008/05/13 09:00 [pubmed]
PHST- 2008/11/06 09:00 [medline]
PHST- 2008/05/13 09:00 [entrez]
AID - S0278-5846(08)00093-6 [pii]
AID - 10.1016/j.pnpbp.2008.03.014 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2008 Jul 1;32(5):1236-42. doi: 
      10.1016/j.pnpbp.2008.03.014. Epub 2008 Mar 25.