PMID- 18472350
OWN - NLM
STAT- MEDLINE
DCOM- 20081008
LR  - 20131121
IS  - 0306-4530 (Print)
IS  - 0306-4530 (Linking)
VI  - 33
IP  - 6
DP  - 2008 Jul
TI  - Functional alterations of the nigrostriatal dopamine system in estrogen 
      receptor-alpha knockout (ERKO) mice.
PG  - 832-8
LID - 10.1016/j.psyneuen.2008.03.007 [doi]
AB  - Estrogen represents an important factor for the development and function of the 
      nigrostriatal dopamine system. Estrogen also controls sex-specific 
      differentiation and activity of the nigrostriatal dopaminergic system. We used an 
      estrogen receptor-alpha knockout (-/-) model (ERKO) to study the influence of 
      this particular receptor subtype on the regulation of functional characteristics 
      of the male and female nigrostriatal dopamine system. On the striatal level, we 
      found a sex-specific regulation of dopamine D1 receptors (D1) and dopamine 
      receptor-interacting protein 78 (Drip78). In female (-/-) mice D1 receptor 
      expression levels were increased compared to wild type (wt) animals, whereas in 
      male (-/-) mice Drip78 mRNA levels were decreased compared to wt. In the 
      midbrain, expression of tyrosine hydroxylase (TH) and brain-derived neurotrophic 
      factor (BDNF) was reduced in (-/-) mice of both sexes. Glial cell line-derived 
      neurotrophic factor (GDNF) expression was not affected. These data demonstrate 
      that the integrity of estrogen receptor-alpha (ERalpha) signalling is necessary 
      for the regulation of gene expression of proteins known to be important for the 
      function of the nigrostriatal system at the postsynaptic striatal and presynaptic 
      midbrain level.
FAU - Kuppers, Eva
AU  - Kuppers E
AD  - Institute of Anatomy, University of Tubingen, D-72076 Tubingen, Germany.
FAU - Krust, Andre
AU  - Krust A
FAU - Chambon, Pierre
AU  - Chambon P
FAU - Beyer, Cordian
AU  - Beyer C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080508
PL  - England
TA  - Psychoneuroendocrinology
JT  - Psychoneuroendocrinology
JID - 7612148
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Drip78 protein, mouse)
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (Glial Cell Line-Derived Neurotrophic Factor)
RN  - 0 (Membrane Proteins)
RN  - 0 (Receptors, Dopamine D1)
RN  - EC 1.14.16.2 (Tyrosine 3-Monooxygenase)
RN  - EC 2.4.2.8 (Hypoxanthine Phosphoribosyltransferase)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/metabolism
MH  - Dopamine/*metabolism
MH  - Estrogen Receptor alpha/*genetics
MH  - Female
MH  - Gene Expression Profiling
MH  - Glial Cell Line-Derived Neurotrophic Factor/genetics/metabolism
MH  - Hypoxanthine Phosphoribosyltransferase/genetics/metabolism
MH  - Male
MH  - Membrane Proteins/genetics/metabolism
MH  - Mesencephalon/metabolism
MH  - Mice
MH  - Mice, Knockout
MH  - Receptors, Dopamine D1/genetics/metabolism
MH  - Sex Characteristics
MH  - Signal Transduction/genetics
MH  - Substantia Nigra/*metabolism/*physiology
MH  - Tyrosine 3-Monooxygenase/genetics/metabolism
EDAT- 2008/05/13 09:00
MHDA- 2008/10/09 09:00
CRDT- 2008/05/13 09:00
PHST- 2007/12/28 00:00 [received]
PHST- 2008/03/19 00:00 [revised]
PHST- 2008/03/24 00:00 [accepted]
PHST- 2008/05/13 09:00 [pubmed]
PHST- 2008/10/09 09:00 [medline]
PHST- 2008/05/13 09:00 [entrez]
AID - S0306-4530(08)00073-5 [pii]
AID - 10.1016/j.psyneuen.2008.03.007 [doi]
PST - ppublish
SO  - Psychoneuroendocrinology. 2008 Jul;33(6):832-8. doi: 
      10.1016/j.psyneuen.2008.03.007. Epub 2008 May 8.