PMID- 18472367
OWN - NLM
STAT- MEDLINE
DCOM- 20080819
LR  - 20191210
IS  - 0360-3016 (Print)
IS  - 0360-3016 (Linking)
VI  - 71
IP  - 4
DP  - 2008 Jul 15
TI  - Maximum-intensity volumes for fast contouring of lung tumors including 
      respiratory motion in 4DCT planning.
PG  - 1245-52
LID - 10.1016/j.ijrobp.2008.03.030 [doi]
AB  - PURPOSE: To assess the accuracy of maximum-intensity volumes (MIV) for fast 
      contouring of lung tumors including respiratory motion. METHODS AND MATERIALS: 
      Four-dimensional computed tomography (4DCT) data of 10 patients were acquired. 
      Maximum-intensity volumes were constructed by assigning the maximum Hounsfield 
      unit in all CT volumes per geometric voxel to a new, synthetic volume. Gross 
      tumor volumes (GTVs) were contoured on all CT volumes, and their union was 
      constructed. The GTV with all its respiratory motion was contoured on the MIV as 
      well. Union GTVs and GTVs including motion were compared visually. Furthermore, 
      planning target volumes (PTVs) were constructed for the union of GTVs and the GTV 
      on MIV. These PTVs were compared by centroid position, volume, geometric extent, 
      and surface distance. RESULTS: Visual comparison of GTVs demonstrated failure of 
      the MIV technique for 5 of 10 patients. For adequate GTV(MIV)s, differences 
      between PTVs were <1.0 mm in centroid position, 5% in volume, +/-5 mm in 
      geometric extent, and +/-0.5 +/- 2.0 mm in surface distance. These values 
      represent the uncertainties for successful MIV contouring. CONCLUSION: 
      Maximum-intensity volumes are a good first estimate for target volume definition 
      including respiratory motion. However, it seems mandatory to validate each 
      individual MIV by overlaying it on a movie loop displaying the 4DCT data and 
      editing it for possible inadequate coverage of GTVs on additional 4DCT motion 
      states.
FAU - Rietzel, Eike
AU  - Rietzel E
AD  - Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical 
      School, Boston, MA 02114, USA. eike@rietzel.net
FAU - Liu, Arthur K
AU  - Liu AK
FAU - Chen, George T Y
AU  - Chen GT
FAU - Choi, Noah C
AU  - Choi NC
LA  - eng
GR  - NCI-P01-21239/PHS HHS/United States
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20080509
PL  - United States
TA  - Int J Radiat Oncol Biol Phys
JT  - International journal of radiation oncology, biology, physics
JID - 7603616
SB  - IM
MH  - Artifacts
MH  - Humans
MH  - Imaging, Three-Dimensional/*methods
MH  - Lung Neoplasms/*diagnostic imaging/*radiotherapy
MH  - *Movement
MH  - Radiographic Image Interpretation, Computer-Assisted/*methods
MH  - Radiotherapy Planning, Computer-Assisted/*methods
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Tomography, X-Ray Computed/*methods
EDAT- 2008/05/13 09:00
MHDA- 2008/08/20 09:00
CRDT- 2008/05/13 09:00
PHST- 2007/08/01 00:00 [received]
PHST- 2008/03/02 00:00 [revised]
PHST- 2008/03/05 00:00 [accepted]
PHST- 2008/05/13 09:00 [pubmed]
PHST- 2008/08/20 09:00 [medline]
PHST- 2008/05/13 09:00 [entrez]
AID - S0360-3016(08)00502-6 [pii]
AID - 10.1016/j.ijrobp.2008.03.030 [doi]
PST - ppublish
SO  - Int J Radiat Oncol Biol Phys. 2008 Jul 15;71(4):1245-52. doi: 
      10.1016/j.ijrobp.2008.03.030. Epub 2008 May 9.