PMID- 18472838
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120910
LR  - 20211020
IS  - 0962-9351 (Print)
IS  - 1466-1861 (Electronic)
IS  - 0962-9351 (Linking)
VI  - 6
IP  - 1
DP  - 1997
TI  - Systemic inflammatory response syndrome (SIRS) induced by carbon tetrachloride in 
      rats.
PG  - 73-4
AB  - We have observed the symptoms of systemic inflammatory response syndrome (SIRS) 
      in male rats intoxicated by carbon tetrachloride (CCl(4)). Severe hypothermia, 
      tachypnoea and increase in the heart beat min were diagnosed. These symptoms 
      developed in the first hour of intoxication. The hepatic dysfunction was 
      characterized by elevated bilirubin levels. In the sera we have measured 
      increases in the activity of secretable (group II) phospholipase A(2) sPLA(2) 
      (2,8x) and 6-ketoprostaglandin F(1alpha) (KPGF) (1,44x). Supposedly the free 
      radicals derived from CCl(4)-mainly trichloromethyl-could induce the prompt 
      reaction of SIRS and the release of sPLA(2) as well as the formation of KPGF. Our 
      findings show that in the early phase of CCl(4) intoxication the symptoms of SIRS 
      can be related to elevation of sPLA(2) and the products of cyclooxygenase II.
FAU - Gergely, J
AU  - Gergely J
AD  - Department of Pharmacology University Medical School Debrecen Debrecen H-4012 
      Hungary.
FAU - Sipka, S
AU  - Sipka S
FAU - Csipo, J
AU  - Csipo J
FAU - Udvardy, M
AU  - Udvardy M
FAU - Szegedi, G
AU  - Szegedi G
FAU - Kulcsar, A
AU  - Kulcsar A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Mediators Inflamm
JT  - Mediators of inflammation
JID - 9209001
PMC - PMC2365841
EDAT- 1997/01/01 00:00
MHDA- 1997/01/01 00:01
PMCR- 1997/02/01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1997/01/01 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
PHST- 1997/02/01 00:00 [pmc-release]
AID - S0962935197000112 [pii]
AID - 10.1080/09629359791974 [doi]
PST - ppublish
SO  - Mediators Inflamm. 1997;6(1):73-4. doi: 10.1080/09629359791974.