PMID- 1847605
OWN - NLM
STAT- MEDLINE
DCOM- 19910322
LR  - 20171213
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 260
IP  - 2 Pt 2
DP  - 1991 Feb
TI  - Brain oxytocin receptors mediate corticotropin-releasing hormone-induced 
      anorexia.
PG  - R448-52
AB  - Central administration of corticotropin-releasing hormone (CRH) is known to 
      inhibit food intake and stimulate pituitary oxytocin (OT) secretion in rats. 
      These experiments addressed the possibility that the inhibition of food intake 
      that follows central CRH administration is mediated through oxytocinergic 
      pathways. Male food-deprived rats, with stable baseline food intakes after 
      intracerebroventricular (icv) injections of artificial cerebrospinal fluid, 
      received 150 pmol of CRH icv. Food intake was inhibited by 62 +/- 5% during a 
      90-min test period. Pretreatment with 9 nmol of the OT antagonist [d(CH2)5, 
      Tyr(Me)2, Orn8]vasotocin icv completely eliminated the inhibition of food intake 
      produced by icv CRH. In contrast, pretreatment with the OT-receptor antagonist 
      did not significantly alter pituitary secretion of adrenocorticotropic hormone 
      and OT stimulated by icv CRH. The results of these experiments implicate OT as a 
      possible central mediator of CRH-induced anorexias in rats, particularly those 
      that are accompanied by stimulation of neurohypophysial OT secretion.
FAU - Olson, B R
AU  - Olson BR
AD  - Department of Medicine, University of Pittsburgh, Pennsylvania 15261.
FAU - Drutarosky, M D
AU  - Drutarosky MD
FAU - Stricker, E M
AU  - Stricker EM
FAU - Verbalis, J G
AU  - Verbalis JG
LA  - eng
GR  - MH-25140/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 0 (Receptors, Angiotensin)
RN  - 0 (Receptors, Oxytocin)
RN  - 50-56-6 (Oxytocin)
RN  - 77327-45-8 (oxytocin,1-(beta-mercapto-(beta, beta-cyclopentamethylene)propionic 
      acid)-Tyr(OMe)(2)-Orn(8)-)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - 9015-71-8 (Corticotropin-Releasing Hormone)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Adrenocorticotropic Hormone/blood
MH  - Animals
MH  - Anorexia/*chemically induced/physiopathology
MH  - Brain/*metabolism
MH  - Corticosterone/blood
MH  - *Corticotropin-Releasing Hormone/pharmacology
MH  - Eating
MH  - Injections, Intraventricular
MH  - Oxytocin/analogs & derivatives/blood/pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Angiotensin/*physiology
MH  - Receptors, Oxytocin
EDAT- 1991/02/01 00:00
MHDA- 1991/02/01 00:01
CRDT- 1991/02/01 00:00
PHST- 1991/02/01 00:00 [pubmed]
PHST- 1991/02/01 00:01 [medline]
PHST- 1991/02/01 00:00 [entrez]
AID - 10.1152/ajpregu.1991.260.2.R448 [doi]
PST - ppublish
SO  - Am J Physiol. 1991 Feb;260(2 Pt 2):R448-52. doi: 10.1152/ajpregu.1991.260.2.R448.