PMID- 18476626
OWN - NLM
STAT- MEDLINE
DCOM- 20110613
LR  - 20181201
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 22
IP  - 3
DP  - 2008 Feb
TI  - [The expressions of TP, MK and CD105 in laryngeal squamous cell carcinoma and 
      their clinical significance].
PG  - 100-3
AB  - OBJECTIVE: To explore the expressions of thymidine phosphorylase (TP), midkine 
      (MK) and MVD marked with CD105 antibody in laryngeal squamous cell carcinoma 
      (LSCC) and their clinical significance. METHOD: The expressions of TP, MK and 
      CD105 in LSCC tissues of 43 cases were studied by immunohistochemical staining. 
      RESULT: The positive expression rates of TP and MK in LSCC were 67.4% and 60.5% 
      respectively, the mean value of MVD was 6.01 +/- 1.78. MVD was significantly 
      higher in tumor tissue with both positive TP and MK than in that with both 
      negative TP and MK (7.07 +/- 3.26 vs. 4.03 +/- 1.90, P < 0.05). The expression of 
      TP, MK and CD105 were all correlated with T-stage and lymph node metastasis. 
      Positive TP, MK expression and high MVD were all associated with a poor survival, 
      and positive expression of both TP and MK in tumors conferred a poorer prognosis 
      than negative expression of those factors in tumors, but only the lymph node 
      metastasis and MVD were independent prognostic factors on multivariate analysis. 
      CONCLUSION: Both TP and MK are important for angiogenesis in LSCC. TP, MK and 
      angiogenesis are all closely correlated with the progress of LSCC and the lymph 
      node metastasis. The lymph node metastasis and MVD marked with CD105 antibody 
      were independent prognostic factors. TP and MK may affect the progression and 
      prognosis of tumor by promotion of angiogenesis. A combinative detection of TP, 
      MK and CD105 can be as valuable tumor marker and prognostic factor for LSCC.
FAU - Liu, Yuying
AU  - Liu Y
AD  - Department of Otolaryngology, Kunming General Hospital of Chengdu Command, 
      Kunming, 650032, China.
FAU - Xue, Xijun
AU  - Xue X
FAU - Wang, Fang
AU  - Wang F
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - 0 (Antigens, CD)
RN  - 0 (ENG protein, human)
RN  - 0 (Endoglin)
RN  - 0 (MDK protein, human)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Receptors, Cell Surface)
RN  - 137497-38-2 (Midkine)
RN  - EC 2.4.2.4 (Thymidine Phosphorylase)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antigens, CD/*metabolism
MH  - Carcinoma, Squamous Cell/blood supply/*metabolism/pathology
MH  - Endoglin
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/blood supply/*metabolism/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Midkine
MH  - Neoplasm Staging
MH  - Neovascularization, Pathologic
MH  - Nerve Growth Factors/*metabolism
MH  - Prognosis
MH  - Receptors, Cell Surface/*metabolism
MH  - Thymidine Phosphorylase/*metabolism
EDAT- 2008/05/15 09:00
MHDA- 2011/06/15 06:00
CRDT- 2008/05/15 09:00
PHST- 2008/05/15 09:00 [pubmed]
PHST- 2011/06/15 06:00 [medline]
PHST- 2008/05/15 09:00 [entrez]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2008 Feb;22(3):100-3.