PMID- 18476630
OWN - NLM
STAT- MEDLINE
DCOM- 20110613
LR  - 20080514
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 22
IP  - 3
DP  - 2008 Feb
TI  - [Expression of Livin in laryngeal squamous cell carcinoma and relationship with 
      bFGF].
PG  - 114-6
AB  - OBJECTIVE: To detect the roles of Livin and its relationship with bFGF in 
      laryngeal squamous cell carcinoma (LSCC) through observing the expression of 
      Livin and bFGF in laryngeal squamous cell carcinoma. METHOD: Expression of Livin 
      and bFGF in 41 cases of LSCC (11 cases with lymph node metastasis) and 20 cases 
      of normal soft palate mucosa were detected by immunohistochemistry. RESULT: Livin 
      were positively detected in 29 (70.73%) cases of LSCC and negatively detected in 
      all normal soft palate tissue. The positive rate of Livin was higher in LSCC than 
      that in normal soft palate tissue and the expressions were significantly 
      associated with lymph node metastasis status (P < 0.05) but not with histological 
      grade, clinical stage and age (P > 0.05). The expression of Livin was positively 
      correlated with the expression of bFGF. CONCLUSION: The elevated expression of 
      Livin in LSCC might play an important role in the development of laryngeal 
      squamous cell carcinoma and bFGF might be involved in the process.
FAU - Zhuo, Xianlu
AU  - Zhuo X
AD  - Department of Otolaryngology, Southwest Hospital, Third Military Medical 
      University, Chongqing, 400038, China. zhuoxianlu@126.com
FAU - Zhao, Houyu
AU  - Zhao H
FAU - Jiang, Zhendong
AU  - Jiang Z
FAU - Chen, Qianmei
AU  - Chen Q
FAU - Chang, Aoshuang
AU  - Chang A
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (BIRC7 protein, human)
RN  - 0 (Inhibitor of Apoptosis Proteins)
RN  - 0 (Neoplasm Proteins)
RN  - 103107-01-3 (Fibroblast Growth Factor 2)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing/*metabolism
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Female
MH  - Fibroblast Growth Factor 2/*metabolism
MH  - Humans
MH  - Inhibitor of Apoptosis Proteins/*metabolism
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Proteins/*metabolism
EDAT- 2008/05/15 09:00
MHDA- 2011/06/15 06:00
CRDT- 2008/05/15 09:00
PHST- 2008/05/15 09:00 [pubmed]
PHST- 2011/06/15 06:00 [medline]
PHST- 2008/05/15 09:00 [entrez]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2008 Feb;22(3):114-6.